Table 1.
MicroRNAs, their direct target genes and cell types in which they play a role during osteogenesis.
| miRNA | Cell Type | Target Gene | Effect on Osteogenesis |
|---|---|---|---|
| let-7a-5p | PMOP BM-MSCs | TGFβR1 | − |
| miR-9 | MSCs | DKK1 | + |
| miR-9-5p | MSCs | Wnt3a | − |
| miR-10b | hASCs | SMAD2 | + |
| miR-16-2-3p | hBM-MSCs | Wnt5a | − |
| miR-17-5p | hBM-MSCs | SMAD7 | + |
| miR-21 | BM-MSCs | SMAD7 | + |
| miR-21-5p | BM-MSCs | SMAD7 | + |
| miR-21a | C3H10T1/2 | SMAD7 | + |
| miR-23a | MSCs, PDLSCs, MC3T3-E1, hBM-MSCs | RUNX2, LRP6 | − |
| miR-23b | MSCs | RUNX2 | − |
| miR-24 | BM-MSCs, MC3T3-E1 | TCF-1 | − |
| miR-26a | BM-MSCs, hASCs | SMAD1, GSK3β | −/+ |
| miR-26b | BM-MSCs | GSK3β | + |
| miR-27a | hFOB1.19, BM-MSCs | APC, SFRP1, GREM1 | −/+ |
| miR-29a | BM-MSCs, MC3TC-E1 | HDAC4 | + |
| miR-29b | BM-MSCs, MC3TC-E1 | HDAC4 | + |
| miR-30 | MC3T3-E1, MSCs, hASCs, C3H10T1/2 | RUNX2, SMAD1 | − |
| miR-30a | MC3T3-E1 | RUNX2, SMAD1 | − |
| miR-30b | MSCs, MC3T3-E1 | RUNX2, SMAD1 | − |
| miR-30c | MSCs, hASCs, MC3T3-E1 | RUNX2, SMAD1 | − |
| miR-30d | MC3T3-E1 | RUNX2, SMAD1 | − |
| miR-30e | hBM-MSCs | LRP6 | − |
| miR-34c | MSCs, MC3T3-E1 | RUNX2 | − |
| miR-93-5p | MSCs, BM-MSCs | BMP2 | − |
| miR-96 | Mice AS cells | SOST | + |
| miR-98 | hMSCs | BMP2 | − |
| miR-100 | hMSCs | BMPR2 | − |
| miR-125b | hBM-MSCs | BMPR1B | − |
| miR-129-5p | MC3T3-E1, C57BL6 | TCF-4 | − |
| miR-132 | UC-MSCs | β-catenin | − |
| miR-133 | C2C12 | RUNX2 | − |
| miR-133a | DPSCs, C2C12 | RUNX2, SMAD5 | − |
| miR-133a-5p | MC3T3-E1 | RUNX2 | − |
| miR-133b | DPSCs | RUNX2, SMAD5 | − |
| miR-135 | C2C12 | SMAD1, SMAD5 | − |
| miR-135a | MSCs, MC3T3-E1, ATDC5, C2C12, DPSCs | RUNX2, SMAD5 | − |
| miR-135a-5p | C2C12 | RUNX2 | − |
| miR-137 | MSCs | RUNX2 | − |
| miR-137-3p | BM-MSCs | RUNX2 | − |
| miR-139-5p | hBM-MSCs | β-catenin, FZD4 | − |
| miR-140-5p | hMSCs | BMP2 | − |
| miR-142-3p | hFOB1.19 | APC | + |
| miR-143 | MSCs | RUNX2 | − |
| miR-144-3p | C3H10T1/2 | SMAD4 | − |
| miR-145 | MC3T3-E1 | CBFB | − |
| miR-146a | hASCs, AS fibroblast | SMAD4, DKK1 | −/+ |
| miR-153 | hMSCs | BMPR2 | − |
| miR-154-5p | hASCs | Wnt11 | − |
| miR-155 | C2C12, MEF | BMPR2 | − |
| miR-195-5p | PDLSCs | BMPR1A | − |
| miR-199b-5p | hBM-MSCs | GSK3β | + |
| miR-203 | MSCs | RUNX2 | − |
| miR-203-3p | MSCs | SMAD1 | − |
| miR-204 | C3H10T1/2, C2C12, ST2, BM-MSCs | RUNX2, BMP2 | − |
| miR-205 | MSCs, BM-MSCs | RUNX2, SATB2 | − |
| miR-208a-3p | MC3T3-E1 | ACVR1/Alk2 | − |
| miR-214 | BM-MSCs | BMP2 | − |
| miR-217 | MSCs | RUNX2, DKK1 | −/+ |
| miR-218 | hASCs, BM-MSCs, MC3T3, hDPSCs | DKK2, SFRP2, SOST, RUNX2 | +/− |
| miR-221 | MSCs | RUNX2 | − |
| miR-221-5p | MB D-MSCs | SMAD3 | − |
| miR-222-3p | BM-MSCs | RUNX2, SMAD5 | − |
| miR-335-5p | MSCs, C3H10T-1/2, MC3T3-E1, MLO-A5, -Y4 | DKK1 | + |
| miR-338 | MSCs | RUNX2 | − |
| miR-338-3p | BM-MSCs mice | RUNX2, FGFR2 | − |
| miR-346 | hBM-MSCs | GSK3β | + |
| miR-370 | MC3T3-E1 | BMP2 | − |
| miR-378 | MSCs | Wnt6, Wnt10a | − |
| miR-381 | hBM-MSCs | Wnt5a, FZD3 | − |
| miR-433-3p | MSCs, hFOB1.19, ROS17/2.8 | DKK1 | + |
| miR-505 | MC3T3-E1 | RUNX2 | − |
| miR-590-3p | hMSCs | APC | + |
| miR-590-5p | C3H10T1/2, MG63, MC3T3-E1 | SMAD7 | + |
| miR-628-3p | MG63 | RUNX2 | − |
| miR-708 | MSCs | SMAD3 | − |
| miR-1297 | hBM-MSCs | Wnt5a | − |