Table 2.
Summary of various polymeric micelles systems for cancer vaccination. LNs: lymph nodes.
| Polymer | Mechanism of Action | Adjuvant and Immunogen | Cancer Type | Reference |
|---|---|---|---|---|
| PEOz-PLA and carboxylated-Pluronic F127 |
LNs targeting | Ova and CL264 | Lymphoma | [84] |
| PEG-PE and PSA | LNs targeting | Trp2 and CpG | Metastatic melanoma | [85] |
| Curcumin-PEG | Reduction of MDSCs and Tregs and increased CD8 T cells | Trp2 | Melanoma | [86] |
| PLGA-PEG | Trp2 | Melanoma | [87] | |
| PSA | DC targeting | Trp2 | Melanoma | [88] |
| PEG-b-PAGE-b-PLGA | - | Ova | - | [89] |
| PLGA-NPs | DC targeting | CD40, Fcg, avb3 and avb5 integrin receptors antibodies | - | [90] |
| P[Asp(DET)]/PEG-b- P[Asp(DET)] | Elevated CTLs and NK | SART3 | Colon cancer | [91,92] |
| PEG-PLL-PLLeu | DC activation | STAT3 siRNA and Ova | Melanoma | [93,94] |