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The fibrinolytic spiral during cancer. In the center, the main fibrinolytic factors and their endogenous inhibitors are depicted, which are surrounded by the pathogenic mechanisms they support. The outer circle summarizes the main hallmarks of cancer described by Hannahan and Weinberg [5]. PAI-1 and PAI-2: plasminogen activator inhibitor-1 and -2, tPA: tissue-type plasminogen activator, uPA: urokinase plasminogen activator.
