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. 2021 Feb 25;13(5):954. doi: 10.3390/cancers13050954

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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STAT3/CDK2/4/6 over expressions are associated with poor prognoses of cancer patients. Kaplan-Meier curve of (A) overall survival (upper panel) and (B) disease-free survival (lower panel) of cancer patients with low and high CDK2/4/6 and (C) STAT3 expressions across TCGA and GTEx datasets. Higher RNA expression profiles of STAT3/CDK2/4/6 correlated with low overall survival and disease-free survival of cancer patients. (D) Representative immunohistochemistry of STAT3/CDK2/4/6 staining across the Human Protein Atlas (HPA) database shows high intensities of CDK2 (antibody: CAB013115), CDK4 (antibody: CAB013116), CDK6, (antibody: HPA002637) and STAT3 (antibody: HPA001671) expressions in clinical samples.