Table 2.

Purity-corrected partial Spearman’s rho value and statistical significance of the correlations of STAT3/CDK2/CDK4/CDK6 expressions with immune infiltration level in diverse cancer types.

Cancer Types	Variable	CDK2		CDK4		CDK6		STAT3
		rho-Value	p-Value	rho-Value	p-Value	rho-Value	p-Value	rho-Value	p-Value
BRCA	Purity	0.173772	3.46 × 10−8	0.093476	0.003164	−0.31833	7.21 × 10−25	−0.10635	0.000779
	B Cell	0.122448	0.000125	0.08921	0.005264	0.240495	2.54 × 10−14	0.066812	0.036797
	CD8+ T Cell	0.192216	1.41 × 10−9	0.032843	0.305355	0.391337	4.53 × 10−37	0.239179	3.65 × 10−14
	CD4+ T Cell	0.140028	1.31 × 10−5	0.042232	0.190619	0.320767	1.85 × 10−24	0.233229	2.38 × 10−13
	Macrophage	0.079207	0.012988	−0.01619	0.612245	0.257793	2.19 × 10−16	0.25456	5.28 × 10−16
	Neutrophil	0.233463	3.07 × 10−13	0.096267	0.002962	0.391841	2.93 × 10−36	0.313132	4.44 × 10−23
	Dendritic Cell	0.169013	1.58 × 10−7	0.113947	0.00043	0.384255	8.01 × 10−35	0.202448	2.97 × 10−10
GBM	Purity	0.286993	2.19 × 10−9	0.430653	2.39 × 10−20	0.192757	7.15 × 10−5	−0.16588	0.000652
	B Cell	−0.05908	0.228103	0.01657	0.73552	0.02255	0.645725	−0.00829	0.865847
	CD8+ T Cell	−0.03756	0.443695	−0.04642	0.343759	0.138459	0.004568	−0.14558	0.002851
	CD4+ T Cell	−0.05077	0.300396	−0.02841	0.562404	−0.0257	0.600353	0.277782	7.64 × 10−9
	Macrophage	−0.01146	0.815223	−0.02026	0.679627	−0.03727	0.447329	0.056771	0.246809
	Neutrophil	0.089753	0.006772	0.052908	0.28049	−0.16547	0.000683	0.175587	0.00031
	Dendritic Cell	0.200704	3.58 × 10−5	0.023584	0.630667	−0.12206	0.012513	0.43801	5.06 × 10−21
HNSC	Purity	0.229737	2.51 × 10−7	0.304761	4.69 × 10−12	−0.06379	0.157308	−0.01693	0.707708
	B Cell	0.110468	0.015902	0.124189	0.00667	−0.21932	1.36 × 10−6	0.230367	3.75 × 10−7
	CD8+ T Cell	0.092891	0.043236	0.07504	0.102739	−0.25071	3.16 × 10−8	0.235486	2.14 × 10−7
	CD4+ T Cell	0.299532	2.09 × 10−11	0.140472	0.002036	0.189753	2.86 × 10−5	0.456441	4.47 × 10−26
	Macrophage	0.146554	0.001238	0.190636	2.47 × 10−5	−0.013	0.775631	0.21852	1.24 × 10−6
	Neutrophil	0.215968	1.84 × 10−6	0.021853	0.6333	0.082199	0.072281	0.346725	5.62 × 10−15
	Dendritic Cell	0.253224	1.73 × 10−8	0.103755	0.00272	0.040238	0.378066	0.387553	1.01 × 10−18
LIHC	Purity	0.181946	0.000672	0.069596	0.196552	−0.11342	0.034946	−0.23257	1.24 × 10−5
	B Cell	0.397861	1.70 × 10−14	0.446746	2.80 × 10−18	0.077473	0.151618	0.167119	0.001869
	CD8+ T Cell	0.300309	1.47 × 10−8	0.327963	5.11 × 10−10	0.024258	0.654848	0.128993	0.016998
	CD4+ T Cell	0.423424	2.13 × 10−16	0.379031	3.39 × 10−13	0.062486	0.247738	0.348425	2.97 × 10−11
	Macrophage	0.476735	9.42 × 10−21	0.51059	4.90 × 10−24	0.097956	0.070829	0.359076	8.16 × 10−12
	Neutrophil	0.477554	4.69 × 10−21	0.368888	1.46 × 10−12	0.076032	0.158794	0.448825	1.67 × 10−18
	Dendritic Cell	0.480477	4.86 × 10−21	0.482455	3.18 × 10−21	0.052521	0.334277	0.285271	8.68 × 10−08
LUAD	Purity	0.06579	0.144252	0.060096	0.182364	−0.16182	0.000304	0.007492	0.868083
	B Cell	−0.04115	0.366308	−0.10408	0.022022	−0.03669	0.420564	0.119856	0.008302
	CD8+ T Cell	0.146119	0.001222	0.006762	0.881683	0.275158	6.57 × 10−10	0.128065	0.004647
	CD4+ T Cell	0.071922	0.001145	−0.09706	0.032783	0.146028	0.001275	0.167818	0.000208
	Macrophage	0.03284	0.470574	−0.01899	0.67652	0.207622	4.01 × 10−6	0.158864	0.000445
	Neutrophil	0.27285	1.08 × 10−9	0.078989	0.082887	0.345911	5.06 × 10−15	0.219087	1.16 × 10−6
	Dendritic Cell	0.134315	0.002949	0.021403	0.637169	0.208912	3.25 × 10−6	0.179555	6.64 × 10−5
SKCM	Purity	0.134716	0.003873	0.33632	1.42 × 10−13	0.208989	6.48 × 10−6	−0.09559	0.040865
	B Cell	−0.04378	0.355269	0.035404	0.454766	0.092088	0.051436	0.190704	4.85 × 10−5
	CD8+ T Cell	−0.025	0.601752	−0.09342	0.050716	0.273715	5.76 × 10−9	0.325874	2.70 × 10−12
	CD4+ T Cell	−0.14917	0.001582	−0.05216	0.271664	0.151926	0.00129	0.276917	2.71 × 10−9
	Macrophage	−0.28478	6.72 × 10−10	−0.06167	0.190155	0.252014	5.42 × 10−8	0.32638	1.05 × 10−12
	Neutrophil	−0.18426	8.13 × 10−5	−0.0556	0.238103	0.455928	1.39 × 10−24	0.500159	5.51 × 10−30
	Dendritic Cell	−0.08306	0.079749	−0.00475	0.920327	0.188403	6.24 × 10−5	0.373995	2.97 × 10−16

Key: rho-value = purity-corrected partial Spearman’s rho value; p-value = statistical significance. SKCE: Skin cutaneous melanoma; LUAD: Lung adenocarcinoma; LIHC: Liver hepatocellular carcinoma; HNSC: Head and neck cancer; GBM: glioblastoma; BRCA: Breast invasive carcinoma.