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. 2021 Feb 25;13(5):956. doi: 10.3390/cancers13050956

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regulation of the transcription factor FOXM1 and its downstream targets by application of thiostrepton (Thio), olaparib (Ola), and carboplatin (CP). (A) Tissue cultures were stained with FOXM1-antibody, representative pictures are shown. (B) Thiostrepton successfully downregulated all investigated gene expressions (FOXM1, BRCA1/2, RAD51). Olaparib, however, upregulated FOXM1 and all downstream targets while the addition of thiostrepton encountered this reaction. Carboplatin treatment only showed increased BRCA1 and thiostrepton could not overcome this effect in overall analysis. n = 3, error bars represent SEM, vehicle CTR was set to 1. (C) #20 expressed counter-regulation by BRCA2 and RAD51 investigating the FOXM1 inhibitor thiostrepton while FOXM1 was effectively downregulated. Vehicle CTR was set to 1. * p < 0.05, ** p < 0.005 (student’s t-test). Significance was not tested for n = 1.