Table 2.

Influences of methyldopa and its combinations with individual flavonoids, at the protein level, on selected factors related to inflammatory processes (TNF-α, IL-1β, and IL-6) and cardiovascular diseases (TGF-β, VEGF, PIGF, and HIF-1α) in JEG-3 cells.

Table. Cont.	TNF-α	TGF-β	VEGF	PIGF	HIF-1α	IL-1β	IL-6
	[ng/mL]
control	0.041 ± 0.002	0.128 ± 0.002	0.174 ± 0.004	3.274 ± 0.055	0.011 ± 0.003	0.008 ± 0.001	0.035 ± 0.006
methyldopa	0.038 ± 0.003	0.095 ± 0.003 *	0.061 ± 0.002 *	3.006 ± 0.028 *	0.052 ± 0.004 *	0.010 ± 0.001	0.035 ± 0.002
apigenin	0.032 ± 0.002 *	0.118 ± 0.001 *	0.203 ± 0.004 *	3.340 ± 0.126	0.011 ± 0.002	0.007 ± 0.001	0.043 ± 0.004
Methyldpa + apigenin	0.029 ± 0.001 *,#	0.091 ± 0.001	0.115 ± 0.002 *,#	3.290 ± 0.001 #	0.025 ± 0.002 #	0.008 ± 0.001	0.046 ± 0.001
baicalein	0.039 ± 0.002	0.113 ± 0.003 *	0.138 ± 0.002 *	3.507 ± 0.031	0.020 ± 0.003	0.009 ± 0.002	0.051 ± 0.008 *
Methyldopa + baicalein	0.030 ± 0.001 *,#	0.087 ± 0.001 *,#	0.122 ± 0.002 *,#	3.405 ± 0.001 #	0.017 ± 0.002 #	0.019 ± 0.001 *,#	0.039 ± 0.001
chrysin	0.035 ± 0.002 *	0.145 ± 0.004 *	0.194 ± 0.004 *	3.325 ± 0.171	0.022 ± 0.003	0.009 ± 0.002	0.033 ± 0.004
methyldopa+ chrysin	0.033 ± 0.001 *	0.107 ± 0.002 *,#	0.144 ± 0.001 *,#	3.341 ± 0.001 #	0.015 ± 0.001 #	0.014 ± 0.001 *	0.043 ± 0.002
quercetin	0.027 ± 0.002 *	0.081 ± 0.002 *	0.131 ± 0.004 *	3.374 ± 0.038	0.019 ± 0.003	0.010 ± 0.001	0.031 ± 0.004
Methyldopa + quercetin	0.035 ± 0.001 *	0.080 ± 0.001 *,#	0.048 ± 0.001 *,#	2.798 ± 0.001 *	0.012 ± 0.001 #	0.013 ± 0.001	0.041 ± 0.002
scutellarin	0.038 ± 0.002	0.141 ± 0.002 *	0.152 ± 0.002 *	3.284 ± 0.160	0.020 ± 0.004	0.011 ± 0.003	0.041 ± 0.005
Methyldopa + scutellarin	0.028 ± 0.001 *,#	0.110 ± 0.002 *,#	0.091 ± 0.001 *,#	3.357 ± 0.001 #	0.027 ± 0.001 *,#	0.014 ± 0.001 *	0.040 ± 0.001

Mean ± SD. *—vs. control, p < 0.05. #—vs. methyldopa, p < 0.05.