Table 1.
Patient characteristics.
| PPFE Group | IPF Group | Control Group | p-Value * | p-Value ** | ||
|---|---|---|---|---|---|---|
| Number | 26 | 30 | 29 | |||
| Age | 61 (56–69) | 65 (60–68) | 66 (58–73) | n/a | n/a | |
| Gender: Male | 17 (65.4%) | 25 (83.3%) | 13 (44.8%) | 0.007 | n/a | |
| Smoker | 14 (56.0%) | 22 (73.3%) | 8 (27.6%) | 0.002 | n/a | |
| Blood biochemistry | ||||||
| KL-6 (IU/mL) | 424 (299–675) | 1182 (753–1642) | n/a | <0.001 | <0.001 | |
| SP-D (IU/L) | 221 (123–353) | 222 (141–321) | n/a | n/a | n/a | |
| Pulmonary function test | ||||||
| FVC (%pred.) | 70.9 (61.9–85.0) | 88.2 (70.1–104.6) | 109.3 (96.8–126.8) | <0.001 | 0.016 | |
| FEV1/FVC (%) | 92.9 (82.7–97.3) | 81.9 (72.6–86.5) | 73.0 (64.5–78.1) | <0.001 | 0.001 | |
| RV/TLC (%) | 43.1 (35.5–49.4) | 30.4 (23.6–34.5) | 34.4 (31.7–38.5) | <0.001 | <0.001 | |
| %DLCO (%pred.) | 83.6 (54.1–89.4) | 65.3 (55.6–84.3) | 87.3 (74.4–99.2) | 0.004 | n/a | |
DLCO, diffusing capacity of the lung for carbon monoxide; FEV1%, forced expiratory volume in 1 s; FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis; KL-6, Krebs von Lunge-6; PPFE, pleuroparenchymal fibroelastosis, RV, residual volume; SP-D, surfactant protein D; TLC, total lung capacity. * among three groups; ** PPFE vs. IPF.