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. 2021 Feb 26;22(5):2346. doi: 10.3390/ijms22052346

Table 2.

Comparing the effects of changes in the expression of orthologous genes on human reproductive potential and on the divergence of the guinea pig and cavy from their nearest common ancestor (NCA) [29].

Humans Animals
Gene Effect of Gene Expression Change (Δ) on Reproductive Potential (♂♀) DEG RNA-Seq Δ during Diver-Gence from NCA
Deficit (↓) ♂♀ Excess (↑) ♂♀ log PADJJ Deficit (↓) Excess (↑)
CETP lesser risk of myo-cardial infarction [47] → hypercholesterolemia in pregnancy [48] ← Cetp 2.1 10−3 wild domestic
CHRNA3 improved finding oppo-site sex congeners [49] → greater nicotine effects on oocytes [50] ← Chrna3 0.9 0.05 wild domestic
CHRNA6 improved maternal behavior [51] → higher risk of social defeats [52] ← Chrna6 0.9 0.05 wild domestic
DRD5 reduces conditioned fear [53] → higher risk of mental disorders [54] ← Drd5 –1.9 10−2 domestic wild
FLT4 suppressed melanoma metastasis [55] → worse post-injury neo- vascularization [56] ← Flt4 0.8 0.05 wild domestic
GFRA3 accelerated neuro-degeneration [57] ← improved neural regeneration [58] → Gfra3 –1.0 0.05 domestic wild
GFRA4 premature adolescent bone formation [59] ← improved neuronal survival [60] → Gfra4 1.5 0.05 wild domestic
HTR3A higher risk of death during pregnancy [61] ← improved mood and behavior [62] → Htr3a –2.9 10−14 domestic wild
IL1B less bone deformation in infections [63] → circadian pain hypersensitivity [64] ← Il1b 2.3 10−2 wild domestic
NR5A1 higher risk of gonadal dysgenesis in men [65] ← improved gonadal development [66] → Nr5a1 –2.2 0.05 domestic wild
PDGFRL reduced tumor mutation burden [67] → myocardial hypertrophy [68] ← Pdgfrl 1.3 10−8 wild domestic
PDYN obesity-related subfertility [69] ← prevented conditioned fear behavior [70] → Pdyn 0.9 10−2 wild domestic
SLC6A4 improved small-intestinal function [71] → worse depression, anxiety, inertia [72] ← Slc6a4 2.9 10−2 wild domestic

Note: see the caption of Figure 1; log, the ratio of a domestic-animal gene expression level to that in wild animals (log2 units); PADJ, significance (Fisher’s Z-test with those corrections on multiple comparisons, which are available within the RNA-Seq data, as published by their authors [26,28,29]).