Table 4.

Comparing the effects of changes in the expression of orthologous genes on human reproductive potential and on the divergence of domestic and wild animals from their nearest common ancestor (NCA).

Humans					Animals
Gene	Effect of Gene Expression Change (Δ) on Reproductive Potential (♂♀)				DEG	RNA-Seq		Δ during Diver-Gence from NCA
	Deficit (↓)	♂♀	Excess (↑)	♂♀		log	PADJJ	Deficit (↓)	Excess (↑)
					domesticated versus wild rabbits [29]
F7	higher risk of bleeding [73]	←	recombinant F7 treats obstetric bleeding [74]	→	F7	–2.7	0.05	domestic	wild
					dog versus wolf (frontal cortex) [29]
PDGFRA	skeletal defects in newborns [75]	←	higher risk of infertility [76]	←	Pdgfra	1.5	10−3	wild	domestic
					dog versus wolf (blood) [28]
GABARAPL2	impaired wound healing [77]	←	improved tooth injury healing [78]	→	Gabarapl2	–2.0	10−2	domestic	wild
GH1	higher risk of mortality [79]	←	prolonged reproductive age in women [80]	→	Gh1	2.8	10−2	wild	domestic
HBB	worse reproductive health in women [81]	←	relieved anemia in kidney diseases [82]	→	Hbbl	–5.9	10−8	domestic	wild
NRP2	better survival after radiochemotherapy [83]	→	vascular neointimal hyperplasia [84]	←	Nrp2	1.8	0.05	wild	domestic
TAC3	higher risk of subfertility [85]	←	lesser socially induced subfertility [85]	→	Tac3	–4.7	10−8	domestic	wild
TGFB3	lowers semen quality and infertility [86]	←	higher risk of female infertility [87]	←	Tgfb3	3.3	0.05	wild	domestic
					tame versus aggressive foxes [26]
ESR2	impaired spermatogenesis [88]	←	impaired spermatogenesis [88]	←	Esr2	–0.3	0.05	domestic	wild
GRIN3A	prevents cocaine addiction [89]	→	higher risk of inatten-tive behavior [90]	←	Grin3a	0.5	10−2	wild	domestic
HTR3B	reduced anger-reso-lutive behavior [91]	←	lesser risk of pulmo-nary embolism [92]	→	Htr3b	–0.5	0.05	domestic	wild
IL6ST	higher risk of mortality during sepsis [93]	←	increased sensitivity to fatigue [94]	←	Il6st	0.3	0.05	wild	domestic
IL9R	impaired trophoblast implantation [95]	←	higher risk of anaphylaxis [96]	←	Il9r	0.4	0.05	wild	domestic
NPY	higher risk of infertility [97]	←	higher risk of obesity and subfertility [98]	←	Npy	0.4	10−2	wild	domestic
TGFB2	higher risk of perinatal mortality [99]	←	impaired wound healing [100]	←	Tgfb2	0.5	10−2	wild	domestic

Note: see the caption of Figure 1 and the footnote of Table 2.