Table 5.
Multivariable model for overall and progression-free survival.
| Overall Survival | Progression-Free Survival | |||||
|---|---|---|---|---|---|---|
| Characteristic | N | Hazard Ratio (95% CI) | p | N | Hazard Ratio (95% CI) | p |
| Any BRCA1 mutation | 67 | 0.76 (0.31–1.89) | 0.557 | 67 | 0.63 (0.29–1.35) | 0.233 |
| Any BRCA2 mutation | 84 | 0.19 (0.03–1.41) | 0.105 | 84 | 0.51 (0.18–1.42) | 0.194 |
| Any BRCA1/2 mutation | 68 | 0.44 (0.19–1.02) | 0.054 | 68 | 0.47 (0.24–0.92) | 0.028 |
| gNon-BRCA HR mutation | 62 | 0.93 (0.26–3.34) | 0.908 | 62 | 1.15 (0.33–4.09) | 0.825 |
| HRD score ≥42 | 78 | 0.69 (0.36–1.30) | 0.250 | 77 | 0.72 (0.42–1.24) | 0.233 |
| HRD score ≥33 | 78 | 0.43 (0.23–0.81) | 0.009 | 77 | 0.62 (0.36–1.06) | 0.078 |
| BRCA1p methylation ≥15 | 70 | 1.41 (0.49–4.00) | 0.522 | 69 | 1.11 (0.38–3.23) | 0.841 |
| Any HRD (HRD score ≥42) 1 | 73 | 0.68 (0.34–1.33) | 0.260 | 71 | 0.70 (0.38–1.27) | 0.240 |
| Any HRD (HRD score ≥33) 2 | 72 | 0.45 (0.23–0.89) | 0.022 | 72 | 0.60 (0.33–1.08) | 0.087 |
gNon-BRCA HR mutation = germline non-BRCA1/2 homologous recombination deficiency mutation. HR = homologous recombination. HR = homologous recombination deficiency. BRCA1p = BRCA1 promoter. Multivariable model adjusted for age, stage, histology, and debulking status; low-grade histologic subtypes were excluded from the models. 1 Any HRD (HRD score ≥42) = germline or somatic BRCA1/2 mutation, germline non-BRCA1/2 homologous recombination deficiency mutation, BRCA1 promoter methylation (≥15), and/or HRD score ≥42). 2 Any HRD (HRD score ≥33) = germline or somatic BRCA1/2 mutation, germline non-BRCA1/2 homologous recombination deficiency mutation, BRCA1 promoter methylation (≥15), and/or HRD score ≥33).