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Functional role and distribution of COMP and TSP-4 in articular cartilage. Schematic representation of COMP and TSP-4 distribution, as well as protein levels in healthy and OA cartilage. Areas of COMP and TSP-4 expression are indicated in blue and green, respectively. Their impact on cartilage and OA relevant processes is depicted in the middle. Green arrows indicate an induction, while red T arrows mean inhibition. PG = proteoglycan and Col = collagen.
