Table 1.
EO | Botanical Name | Family | Part Used | Hazard(s) | Toxic Component(s) | Oil Composition | Maximum Oral Dose in Pregnancy [22] | Ref. |
---|---|---|---|---|---|---|---|---|
Anise or aniseed | Pimpinella anisum L. | Apiaceae | Seeds | Reproductive hormone modulation | (E)-Anethole | (E)-anethole (75.2–96.1%), d-limonene (tr–4.9%), and estragole (0.5–5.0%) | - | [23,24] |
Aniseed Myrtle | Syzygium anisatum (Vickery) Craven and Biffin | Myrtaceae | Leaves | Reproductive hormone modulation | (E)-Anethole | (E)-anethole (95.0%), and estragole (4.4%) | - | [25] |
Araucaria | Neocallitropsis pancheri (Carriere) de Laub. (synonym: Callitropsis araucarioides Compton, and Neocallitropsis araucarioides (Compton) Florin) | Cupressaceae | Wood | Fetotoxic, anti-angiogenic | β-Eudesmol | β-eudesmol (25.9%), γ-eudesmol (19.0%), α-eudesmol (13.3%), guaiol (6.0%), elemol (5.0%), and β-bisabolenol (4.9%) | - | [26] |
Atractylis (Cang-zhu atractylodes) | Atractylodes lancea (Thunb.) DC | Asteraceae | Roots | Anti-angiogenic, fetotoxic | β-Elemene and β-eudesmol | β-eudesmol (26.0%), β-elemene (18.0%), hinesol (10.0%), and elemol (6.0%) | - | [22] |
Australian Lemon balm (lemon-scented ironbark) | Eucalyptus staigeriana F. v. Muell. ex F. M. Bailey | Myrtaceae | Leaves | Teratogenicity | Citral | d-limonene+ β-phellandrene (30.5%), geranial (9.9%), neral (7.7%), α-phellandrene (7.1%), and terpinolene (6.6%) | 238 mg/day based on 17.6% citral content | [22] |
Basil oil (estragole chemotype) | Ocimum basilicum L. | Lamiaceae | Leaves | Potentially carcinogenic | Estragole and methyleugenol | estragole (73.4–87.4%), linalool (tr–8.6%), and 1,8-cineole (0.6–6.0%) | - | [23] |
Bitter Fennel | Foeniculum vulgare Mill. subsp. capillaceum Gilib. | Apiaceae | Seeds | Reproductive hormone modulation | (E)-anethole | (E)-anethole (52.5–84.3%), fenchone (4.0–24.0%), α-pinene (tr-10.4%), d-limonene (0.5–9.4%), and estragole (2.8–6.5%). | - | [23] |
Black seed (black cumin or black caraway) | Nigella sativa L. | Ranunculaceae | Seeds | Fetotoxic | Thymoquinone | thymoquinone (26.8–54.8%), p-cymene (14.7–38.0%), longifolene (1.2–10.2%), and α-thujene (1.3–10.1%) as the main constituents. | - | [27] |
Blue Cypress (Northern cypress pine) | Callitris intratropica R.T. Baker and H.B. Sm. | Cupressaceae | Wood | Fetotoxic, anti-angiogenic | β-Eudesmol | β-eudesmol (14.4%), dihydrocolumellarin (14.0%), guaiol (13.7%), γ-eudesmol (9.1%), α-eudesmol (7.6%), guaiazulene (6.2%), chamazulene (5.6%) | - | [28] |
Buchu (diosphenol chemotype) | Agathosma betulina Bergius | Rutaceae | Leaves | Abortifacient; hepatotoxicity | Pulegone | isomenthone (4.6–29.1%), limonene (11.6–28.2%), disophenol (12.0–26.3%), menthone (2.5–25.0%), c-diosphenol (10.3–23.3%), and 8-mercapto-p-menthan-3-one(cis-trans) (0.7–6.6%) | - | [29] |
Buchu (pulegone chemotype) | Agathosma crenulata L. | Rutaceae | Leaves | abortifacient | Pulegone | (1R)-(+)-β-pulegone (31.6–73.2%), isomenthone (3.6–27.6%), limonene (2.1–17.2%), (E)-8-acetylthio-p-menthan-3-one (0.4–10.4%), and menthone (1.3–7.0%) | - | [29,30] |
Carrot seed | Daucus carota L. subsp. sativus Hoffm. | Apiaceae | Seeds | antigestational effects | carotol (36.1–73.1%), α-pinene (0.9–11.2%), dauca-4,8-diene (1.6–5.9%), and β-caryophyllene (0.7–5.6%) | - | [31] | |
Cassia (Chinese or false cinnamon) | Cinnamomum cassia (L.) J. Presl (synonym: Cinnamomum aromaticum Nees) | Lauraceae | Leaves, terminal branches and bark | Embryotoxicity, reproductive toxicity | Methyleugenol and cinnamaldehyde | (E)-cinnamaldehyde (73.2–89.4%), (Z)-cinnamaldehyde (0.8–12.3%), and (E)-cinnamyl acetate (0.1–5.4%) while in the leaf oil (E)-cinnamaldehyde (54.6–90.1%), (E)-cinnamyl acetate (1.4–12.5%), (Z)-cinnamaldehyde (0.4–10.5%), and benzaldehyde (1.1–6.3%) | - | [32] |
Chaste tree (Monk’s pepper) | Vitex agnus-castus L. | Verbenaceae | Leaves | Reproductive hormone modulation | The oil may contain methyleugenol | Leaf EO: 1,8-cineole (15.6–35.2%), sabinene (6.9–17.1%), α-pinene (1.0–13.9%), α-terpineol (1.4–9.2%), γ-elemene (0–9.1%), β-selinene (0–9.0%), β-caryophyllene (2.3–8.9%), (Z)-β-farnesene (0–8.6%), citronellyl acetate (0.3–7.8%), and citronellic acid (0–6.6%). Seed EO: sabinene (7.1–44.1%), 1,8-cineole (8.4–23.3%), α-pinene (1.2–23.1%), γ-elemene (0–17.0%), (E)-β-farnesene (0–10.3%), β-caryophyllene (0.8–9.3%), α-terpineol (0.2–9.3%), limonene (0.5–7.4%), (Z)-β-farnesene (0–6.9%), citronellyl acetate (0.2–6.0%), β-selinene (0–6.0%), and β-myrcene (0–5.6%). |
- | [33,34] |
Cinnamon bark | Cinnamomum verum J. Presl. (Synonym: Cinnamomum zeylanicum Blume) | Lauraceae | Dried inner bark of young trees | Embryotoxicity | (E)-Cinnamaldehyde | (E)-cinnamaldehyde (63.1–75.7%), eugenol (2.0–13.3%), (E)-cinnamyl acetate (0.3–10.6%), linalool (0.2–7.0%), and β-caryophyllene (1.3–5.8%) | - | [23,24] |
Costus | Saussurea costus (Falc.) Lipsch. (synonym: Aplotaxis lappa Decne., Aucklandia costus Falc., Saussurea lappa (Decne) C.B. Clarke) | Asteraceae | Dried roots | Fetotoxicity, anti-angiogenicity | Costunolide and dehydrocostus lactone | aplotaxene (20.0%), dihydrocostus lactone (15.0%), costusic acid (14.0%), costunolide (11.0%), dehydrocostus lactone (6.0%), and dihydrodehydrocostus lactone (6.0%) | - | [35] |
Dalmatian Sage | Salvia officinalis L. | Lamiaceae | Leaves | embryotoxic | Camphor, thujones | camphor (7.3–50.2%), α-thujone (13.1–48.5%), borneol (1.5–23.9%), 1,8-cineole (1.8–21.7%), β-thujone (3.9–19.1%), β-caryophyllene (0.2–9.7%), camphene (0–8.6%), α-pinene (0–8.0%) and bornyl acetate (0.3–5.7%) | - | [36] |
Feverfew (nosebleed or midsummer daisy) | Tanacetum parthenium (L.) Sch. Bip. (synonym: Chrysanthemum parthenium (L.) Bernh.) | Asteraceae | Leaves | Unsafe, moderately neurotoxic | Camphor | camphor (28.0–44.2%), (E)-chrysanthenyl acetate (22.9–30.2%), camphene (5.4–7.7%), and germacrene D (0.7–4.6%) | - | [37] |
Genipi (Genepi) | Artemisia genepi Weber. (synonym: A. spicata Wulfen, and A. mutellina Vill.) | Asteraceae | Aerial parts | Neurotoxic | Thujone | α-thujone (79.8%) and β-thujone (10.4%) | - | [38] |
Great Mugwort | Artemisia arborescens L. | Asteraceae | Aerial parts | Neurotoxic | Thujone | β-thujone (34.0%), chamazulene (22.4%), and camphor (11.8%) | - | [39] |
Green Yarrow (Ligurian yarrow) | Achillea nobilis L. (synonym: A. ligustica Vis. ex Nym.) | Asteraceae | Aerial parts of the flowering plant | Abortifacient | Sabinyl acetate; camphor | camphor (13.7%) artemisia alcohol (9.2%), germacrene D (8.8%), artemisia ketone (8.7%) and viridiflorol (5.7%) | - | [22] |
Ho leaf (camphor chemotype) | Cinnamomum camphora (L.) J.Presl | Lauraceae | Leaves | Neurotoxic | Camphor | camphor (37.8–84.1%), 1,8-cineole (1.0–12.0%), and terpinen-4-ol (0.9–6.3%) | - | [40] |
Honey Myrtle (Marsh honey myrtle) | Melaleuca teretifolia Endl. | Myrtaceae | Leaves | Teratogenicity | Citral | geranial (37.5%), neral (29.0%) and β-myrcene (10.9%) | 63 mg/day based on 66.5% citral content | [22] |
Hyssop (pinocamphone chemotype) | Hyssopus officinalis L. | Lamiaceae | Leaves and flowering tops | Neurotoxicity; carcinogen | Pinocamphone, methyleugenol | pinocamphone (31.2–42.7%), isopinocamphone (30.9–39.2%) and β-pinene (4.0–8.8%) | - | [37,41] |
Indian dill seed (Sowa) | Anethum sowa Roxb. ex Flem. | Apiaceae | Seeds | hepatotoxic, nephrotoxic, Abortifacient | Dill apiole | dill apiole (20.7–52.5%), d-limonene (5.9–45.0%), (+)-carvone (17.4–23.1%), (E)-dihydrocarvone (4.2–16.6%), α-phellandrene (tr–6.5%), and (Z)-dihydrocarvone (0.8–5.2%) | - | [32] |
Lanyana (African wormwood) | Artemisia afra Jacq. ex Willd. | Asteraceae | Leaves and stems | neurotoxic | Thujone | α-thujone (22.5%), (E)-chrysanthenyl acetate (19.2%), 1,8-cineole (19.1%), camphor (11.0%), and β-thujone (8.9%) | - | [22] |
Lemon basil | Ocimum × africanum Lour. | Lamiaceae | Leaves | Teratogenicity | Citral | geranial (23.3–25.1%), neral (16.0–17.1%), nerol (13.0–15.3%), linalool (5.0–7.8%), and (E)-α-bisabolene (5.3–6.2%) | 99 mg/day based on 42.2% citral content | [22] |
Lemon leaf (lemon petitgrain) | Citrus × limon L. (synonym: Citrus limonum Risso) | Rutaceae | Leaves | Teratogenicity | Citral | geranial (10.9–39.0%), limonene (8.1–30.7%), neral (6.5–25.3%), geraniol (0.5–15.0%), β-pinene (3.5–13.6%), neryl acetate (3.7–7.4%), nerol (1.3–7.4%), α-terpinyl acetate (tr–7.3%), and linalyl acetate (tr–6.5%) | 84 mg based on 50% citral content | [32] |
Lemon Myrtle (lemon ironwood or sweet verbena tree) | Backhousia citriodora F. Muell. | Myrtaceae | Leaves | Teratogenicity | Citral | geranial (46.1–60.7%) and neral (32.0–40.9%) | 46 mg/day | [42] |
Lemon Thyme | Thymus citriodorus (Pers.) Schreb. (Synonyms: Thymus lanuginosus Mill. var. citriodorum Pers., Thymus serpyllum var. citriodorus (Hort.), Thymus serpyllum L. var. vulgaris Benth.); a cross between Thymus vulgaris and Thymus pulegioides. | Lamiaceae | Aerial parts | Teratogenicity | Citral | geraniol (39.2%), carvacrol (15.4%), geranial (9.2%) and neral (7.1%) | 258 mg/day based on 16.3% citral content | [43] |
Lemongrass | Cymbopogon flexuosus Nees ex Steud. (synonym.: Andropogon flexuosus Nees ex Steud.) (East Indian) and Cymbopogon citratus DC (synonym: Andropogon citratus DC) (West Indian) | Poaceae | Leaves | Teratogenicity | Citral |
|
46 mg/day based on 90% citral content | [41,44,45] |
Lemon-scented tea tree (lemon tea tree) | Leptospermum petersonii F. M. Bailey (synonym: Leptospermum citratum Chall., Cheel and Penf.; Leptospermum liversidgei R.T. Baker and H. G. Smith) | Myrtaceae | Aerial parts | Teratogenicity | Citral | geranial (45.4%), neral (31.3%), α-pinene (12.3%), and citronellal (6.8%) | 54 mg/day based on 77% citral content | [46] |
Lesser Calamint (Cuckoo flower, field balm, and nepitella) | Calamintha nepeta L. subsp. glandulosa Req. (synonym: Calamintha officinalis Moench.) | Lamiaceae | Aerial parts | Abortifacient; hepatotoxicity | Pulegone | (1R)-(+)-β-pulegone (17.6–76.1%), menthone (7.0–55.8%), piperitone oxide (0–12.4%), piperitone (0–7.4%), piperitenone (0–7.3%), limonene (0.6–7.2%), and terpinen-4-ol (0–6.8%). | - | [47] |
May chang (Pheasant pepper tree) | Litsea cubeba (Lour.) Pers. (synonyms: Litsea citrata Blume, Laurus cubeba Lour.) | Lauraceae | Fruits | Teratogenicity | Citral | geranial (37.9–40.6%), neral (25.5–33.8%), limonene (8.4–22.6%), and methyl heptenone (0.5–4.4%) | 56 mg/day based on 74% citral content | [41,48] |
Melissa (lemon balm) | Melissa officinalis L. | Lamiaceae | Fresh aerial parts | Teratogenicity | Citral | geranial (12.5–38.3%), neral (9.7–26.1%), β-caryophyllene (0.3–19.1%), citronellal (4.5–13.3%), germacrene D (0–13.0%), caryophyllene oxide (0.8–10.0%), and geraniol (1.0–8.1%) | 65 mg/day based on 64% citral content | [37,48] |
Mugwort (chrysanthenyl acetate CT) | Artemisia vulgaris L. | Asteraceae | Aerial parts | slightly neurotoxic | Thujone | chrysanthenyl acetate (31.7–32.8%) and germacrene D (12.1–15.9%) | - | [22] |
Mugwort or Indian wormwood oil (camphor/thujone CT) | Artemisia vulgaris L. | Asteraceae | Aerial parts of flowering plant | Slightly neurotoxic | Thujone | camphor (20.8%), artemisia alcohol (15.3%), α-thujone (11.4%), β-caryophyllene (10.6%), isoborneol (9.3%), 1,8-cineole (9.0%), and sabinene (6.1%) | - | [49] |
Myrrh (Somalian myrrh) | Commiphora myrrha (Nees) Engl. (synonym: Commiphora molmol Engl.) | Burseraceae | Dried gum oleoresin | Fetotoxic, anti-angiogenic | β-Elemene and furanodiene | furanoeudesma-1,3-diene (34.0%), furanodiene (19.7%), lindestrene (12.0%), and β-elemene (8.7%) | - | [50] |
Nasturtium (Indian cress) absolute | Tropaeolum majus L. | Tropaeolaceae | Flowers | fetal toxicity | Benzyl cyanide, benzyl isothiocyanate | benzyl isothiocyanate (72.3%), unidentified nitrogen compound (16.0%), and benzyl cyanide (2.0%) | - | [22] |
Nutmeg | Myristica fragrans Houtt (Synonyms: Myristica officinalis L. fil., Myristica moschata Thunb., Myristica aromatica O. Schwartz, and Myristica amboinensis Gand.) | Myristicaceae | Kernels | Potentially carcinogenic; reduced fertility | Safrole, methyleugenol, myristicin |
|
- | [32,51] |
Orange Champaca (golden champa, champak) absolute | Michelia champaca L. | Magnoliaceae | Flowers | Toxic | 2-Phenylethanol | 2-phenylethanol (25.0–34.0%), methyl linoleate (10.0–18.0%), indole (2.9–12.0%), methyl anthranilate (2.1–9.0%), and methyl benzoate (1.0–5.0%) | - | [52] |
Oregano | Origanum onites L. (synonym: Origanum smyrnaeum L.); Origanum vulgare L. subsp. hirtum (Link) Ietswaart (synonym: Origanum compactum, Origanum hirtum Link); and Thymbra capitata (L.) Cav. (synonym: Thymus capitatus L., Coridothymus capitatus L., Satureja capitata L.) | Lamiaceae | Dried aerial parts of flowering plant | embryotoxic | Not identified |
|
- | [53,54,55,56] |
Parsley leaf | Petroselinum crispum Mill (synonym: P. sativum Hoffm., and P. hortenseauct) | Apiaceae | Leaves | abortifacient | Parsley apiole | Egyptian parsley: p-mentha-1,3,8-triene (6.2–45.2%), β-myrcene (7.8–23.8%), β-phellandrene (6.7–19.5%), myristicin (1.9–8.8%), α-pinene (6.9–7.6%), terpinolene (2.8–6.6%), limonene (3.3–5.4%), α-p-dimethylstyrene (2.7–5.4%), and dill apiole (0.2–5.2%) | - | [22,57] |
Parsley seed | Petroselinum crispum Mill | Apiaceae | Seeds | abortifacient | Parsley apiole | parsley apiole (11.3–67.5%), myristicin (0.7–37.9%), allyltetramethoxybenzene (0.6–29.0%), α-pinene (8.3–16.9%), β-pinene (5.4–10.7%), and elemicin (0–8.8%) | - | [58] |
Pennyroyal | Hedeoma pulegioides L. (N. American); Mentha pulegium L. (European) and Micromeria fruticosa L. (Turkish) | Lamiaceae | Fresh aerial parts | abortifacient | Pulegone |
Hedeoma pulegioides: (1R)-(+)-β-pulegone (61.3–82.3%) and isomenthone (0.8–31.0%). Mentha pulegium: (1R)-(+)-β-pulegone (67.6–86.7%), menthone (1.5–16.0%) and isomenthone (0.8–8.6%). Micromeria fruticosa: (1R)-(+)-β-pulegone (66.7%) and isomenthone (11.1%). |
- | [23] |
Plectranthus | Plectranthus fruticosus L’Hérit | Lamiaceae | Leaves | embryotoxic, fetotoxic, teratogenic and abortifacient | Sabinyl acetate | sabinyl acetate (> 60.0%) | - | [59] |
Rue | Ruta graveolens L. and Ruta montana Mill | Rutaceae | Aerial parts | abortifacient | Not identified |
|
- | [60,61,62] |
Savin | Juniperus sabina L. | Cupressaceae | Leaves and terminal branches | embryo-fetotoxic, abortifacient and hepatotoxic | trans-Sabinyl acetate | trans-sabinyl acetate (19.1–53.1%), sabinene (18.3–40.8%), and elemol (tr–7.0%) | - | [23] |
Sea Wormwood | Artemisia maritima L. (synonyms: Artemisia contra Willd. ex Spreng., Artemisia lercheana Kar. and Kir., Artemisia salina Willd., Seriphidium maritimum (L.) Poljakov) | Asteraceae | Leaves and flowering tops | neurotoxic | Thujone | α-thujone (63.3%), sabinene (7.8%) and 1,8-cineole (6.5%) | - | [63] |
Spanish Lavender (French lavender or maritime lavender) | Lavandula stoechas L. ssp. stoechas | Lamiaceae | Flowering tops | neurotoxic | Camphor | camphor (16.4–56.2%), (+)-fenchone (14.9–49.1%), 1,8-cineole (3.6–14.5%), α-pinene (3.4–4.5%), and camphene (2.8–5.5%) | - | [64] |
Spanish Sage (lavender sage) | Salvia lavandulifolia Vahl (synonym: Salvia hispanorum Lag) | Lamiaceae | Flowering tops | abortifacient | Sabinyl acetate |
|
- | [23,65] |
Star anise | Illicium verum J.D. Hook. | Illiciaceae | Fruits | reproductive hormone modulation | (E)-Anethole | (E)-anethole (71.2–91.8%), foeniculin (0.5–14.6%), estragole (0.3–6.6%), and d-limonene (0.7–5.0%) | - | [23] |
Sweet Birch (black birch or southern birch) | Betula lenta L. | Betulaceae | Bark | reproductively toxic | Methyl salicylate and ethyl salicylate | methyl salicylate (90.4%) and ethyl salicylate (5.5%) | - | [22] |
Sweet Fennel | Foeniculum vulgare Mill. | Apiaceae | Seeds | Reproductive hormone modulation | (E)-Anethole | (E)-anethole (58.1–92.5%), d-limonene (0.2–21.0%), fenchone (0.2–8.0%), and estragole (1.1–4.8%) | - | [23,24] |
Tansy | Tanacetum vulgare L. (synonyms: Chrysanthemum tanacetum Karsch, and Chrysanthemum vulgare L.) | Asteraceae | Aerial parts | neurotoxic | Thujone | β-thujone (45.2%), artemisia ketone (10.5%), borneol (7.8%), and bornyl acetate (7.7%) | - | [22] |
Thuja (cedar leaf, white cedar, eastern white cedar, eastern arborvitae, or swamp cedar) | Thuja occidentalis L. | Cupressaceae | Fresh leaves and terminal branches | neurotoxic | Thujone | α-thujone (48.7–51.5%), fenchone (12.2–12.8%) and β-thujone (7.9–9.9%) | - | [22,66] |
Verbena (lemon verbena) | Aloysia triphylla L’Hérit (Synonyms: Aloysia citriodora Ortega ex Pers., Lippia citriodora Ortega ex Pers., and Lippia triphylla L’Hérit) | Verbenaceae | Leaves | Teratogenicity | Citral | geranial (29.5–38.3%), neral (22.9–29.6%), and limonene (5.7–15.4%) | 61 mg/day based on 68% citral content | [67] |
Western red cedar (pacific thuja or western arborvitae) | Thuja plicata Donn ex D. Don | Cupressaceae | Needles (leaves) | neurotoxic | Thujones | α-thujone (63.5–84.0%), β-thujone (4.9–15.2%), and sabinene (1.1–8.8%) | - | [68] |
White Wormwood (armoise or desert wormwood) α-thujone/camphor chemotype | Artemisia herba-alba Asso | Asteraceae | Leaves and flowering tops | neurotoxic | Thujones; camphor | camphor (34.0–55.0%), α-thujone (25.7–36.8%), β-thujone (2.0–9.0%), camphene (0.5–9.0%), and 1,8-cineole (1.5–8.0%) | - | [32,41,69] |
Wintergreen | Gaultheria fragrantissima Wall. and Gaultheria procumbens L. | Ericaceae | Leaves | high doses are teratogenic | Methyl salicylate |
|
- | [22] |
Wormwood (Absinthe) | Artemisia absinthium L. | Asteraceae | Leaves and flowering tops | embryo-fetotoxicity; abortifacient | Sabinyl acetate; Thujone |
|
- | [23,39] |
Zedoary (white turmeric, hidden ginger) | Curcuma zedoaria Roscoe | Zingiberaceae | Rhizome | antifertility; embryotoxicity, antigestational and abortifacient | Not identified | epicurzerene (19.0–46.6%), curzerene (10.4%), curdione (7.0–19.6%), curzerenone (22.3–31.6%), debromofiliforminol (31.5%), 1,8-cineole (18.5–40.8%), β-sesquiphellandrene (21.5%), p-cymene (18.4%), curcumenene (18.7%), and α-phellandrene (14.9%) | - | [66,70,71,72,73] |