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Diabetes- and high-fat (HF) diet-exposed newborn males had significant cardiac dysfunction at birth. (A) Systolic function, (B) diastolic function, (C) heart rate and stroke volume were determined in P1 offspring by echocardiography. (D) Cardiac output was calculated from (C). N = 12–19 offspring/group. Significant differences (p ≤ 0.05): + diabetes or * diet effect by 2-way NOVA.
