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MtDNA plays a role in respiratory boost of mitochondrial transfer. (A) Basal, (B) FCCP-stimulated maximal, and (C) reserve respiratory capacities of CM treated with sham (solid), living–respiring (black hashing), “killed” (red hashing), and “killed”+DNase-treated mitochondria (diagonal). N = 4–6 per group. Data represent mean ± SEM. P ≤ 0.05: # mitochondrial effect by 1-way ANOVA. ** P < 0.01.
