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. 2021 Mar 10;14:681–691. doi: 10.2147/JPR.S288289

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© 2021 Lian et al.

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Effects of hydrogen-rich water on the expression of LPS and TLR4 in CINP mice. (A) The expression of LPS was detected in the DRG, spinal cords and serum of mice by ELISA in each group. (B) The expression of TLR4 was detected in the DRG, spinal cords and serum of mice by ELISA in each group. (C) The expression of TLR4 was detected by Western blot analysis. (D) Quantitative analysis of TLR4 is presented as the ratio of band density to that of β-actin. n=5 mice per group. *P<0.05 vs H₂O + Saline group; ^&P<0.05 vs HW + Saline group; ^#P<0.05 vs H₂O + OXA group.

Abbreviations: LPS, lipopolysaccharide; TLR4, Toll-like receptor 4; CINP, chemotherapy-induced neuropathic pain; DRG, dorsal root ganglia.