Table 5.

Impact of systemic SS manifestations on quality of life (n=2961)

Lung Disease (n=305)	Adjusted OR (95% Cl)
Challenge & Burden	1.81 (1.37–2.37)
Function Interference	1.97 (1.41–2.75)
Financial Burden	1.96 (1.44–2.67)
Ability to Work	1.64(1.13–2.39)
Mood	1.05 (0.80–1.39)
ADLs	2.63 (2.01–3.44)
Memory & Concentration	2.10 (1.60–2.75)
Relationship	1.93 (1.45–2.56)
Diet	1.37 (1.05–1.78)
Purpura/Petechiae/Cryoglobulinemia (n=162)
Challenge & Burden	1.82 (1.27–2.63)
Function Interference	1.50 (0.99–2.27)
Financial Burden	1.83 (1.21–2.76)
Ability to Work	1.74(1.08–2.81)
Mood	1.02 (0.71–1.47)
ADLs	1.81 (1.28–2.57)
Memory & Concentration	1.02 (0.72–1.46)
Relationship	1.31 (0.89–1.91)
Diet	2.02 (1.44–2.86)
Vasculitis (n=238)
Challenge & Burden	1.38 (1.02–1.86)
Function Interference	1.01 (0.73–1.40)
Financial Burden	1.07 (0.78–1.47)
Ability to Work	0.94 (0.63–1.40)
Mood	0.74 (0.54–1.01)
ADLs	1.01 (0.74–1.37)
Memory & Concentration	1.03 (0.76–1.39)
Relationship	1.16 (0.83–1.61)
Diet	1.10 (0.82–1.48)
Neuropathy (n=1120)
Challenge & Burden	1.74 (1.47–2.05)
Function Interference	1.94 (1.60–2.35)
Financial Burden	1.59 (1.33–1.91)
Ability to Work	1.58 (1.27–1.97)
Mood	1.43 (1.20–1.70)
ADLs	1.74 (1.46–2.07)
Memory & Concentration	1.85 (1.56–2.20)
Relationship	1.65 (1.36–2.00)
Diet	1.46 (1.23–1.73)
Interstitial Nephritis (n=30)
Challenge & Burden	3.06 (1.21–7.76)
Function Interference	9.60 (1.29–71.47)
Financial Burden	2.03 (0.75–5.50)
Ability to Work	5.25 (1.08–25.4)
Mood	2.64 (1.18–5.88)
ADLs	2.50 (1.10–5.66)
Memory & Concentration	2.49 (1.06–5.83)
Relationship	1.85 (0.79–4.32)
Diet	1.67 (0.76–3.67)

All models are adjusted for age, sex, race, and employment status. Bolded confidence interval (CI) =p<0.05. Referent value = never.