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. 2021 Mar 1;13:600484. doi: 10.3389/fnagi.2021.600484

Figure 2.

Figure 2

Effects of lipopolysaccharide (LPS) exposure and elamipretide (SS-31) treatment on oxidative stress. (A) LPS exposure caused a significant mitochondrial ROS (mtROS) increase while rats with SS-31 treatment have lower level. (B,C) LPS exposure and SS-31 treatment caused superoxide dismutase (SOD) changes in the hippocampus. (D–F) LPS exposure and SS-31 treatment caused electron transport chain (ETC) complex I/III/IV changes in the hippocampus. Data are presented as mean ± SEMs (n = 5). Comparisons were made by two-way ANOVA followed by the Bonferroni post-hoc analysis. *p < 0.05, **p < 0.01, ***p < 0.001 vs. LPS (L) group.