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. 2021 Mar 1;13:600484. doi: 10.3389/fnagi.2021.600484

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Copyright © 2021 Liu, Fu, Wu, Nie, Liu, Wang, Xiao, Yang, Kan and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SS-31 treatment induced both short- and long-term functional connectivity (FC) changes in the aged rat brain. (A) SS-31 treatment caused FC changes in 3 days. SS-31 treatment improved FC connectivity in (B) 7 days and (C) 31 days. (D–F) Localization for different regions of interest (ROIs) on day 3, 7, and 31. Data were analyzed by one-way ANOVA followed by the post-hoc two-sample t-test. A voxel-level height threshold of p < 0.001 and a cluster-extent threshold of 20 were considered as statistically significant. Both the left and right hippocampus were used as seed voxels.