Table 5.

Multivariate analysis of baseline characteristics and inflammatory biomarkers for the prediction of OS and PFS.

Variables	OS		Variables	PFS
	HR (95% CI)	P		HR (95% CI)	P
Metastasis			Local or distant metastases
M1a			M1a
M1b	1.66 (1.00–2.75)	0.05	M1b	1.87 (1.18–2.97)	0.08
M1c	1.84 (1.10–3.08)	0.02	M1c	2.36 (1.50–3.71)	<0.001
Cerebral			Cerebral
No			No
Yes	1.40 (0.98–2.00)	0.07	Yes	1.32 (0.95–1.82)	0.10
Bones			Bones
No			No
Yes	0.97 (0.67–1.39)	0.86	Yes	0.96 (0.70–1.32)	0.82
Chemotherapy			Adrenal
No chemotherapy			No
First-line treatment	0.60 (0.43–0.84)	0.003	Yes	1.39 (0.81–2.40)	0.23
Second-line treatment	1.22 (0.53–2.81)	0.65	Radiotherapy
Radiotherapy			No
No			Yes	1.17 (0.87–1.58)	0.29
Yes	1.22 (0.87–1.70)	0.25	EGFR-TKI
AGR			No
Low			Yes	1.09 (0.81–1.47)	0.57
High	0.55 (0.35–0.86)	0.009	AGR
LDH			Low
Low			High	0.55 (0.37–0.83)	0.004
High	1.12 (0.78–1.60)	0.55	LDH
TG			Low
Low			High	1.16 (0.87–1.55)	0.32
High	1.40 (1.02–1.94)	0.04
PNI
Low
High	0.56 (0.39–0.80)	0.02
LMR
Low
High	0.83 (0.59–1.18)	0.31