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. 2021 Feb 1;28(2):169–180. doi: 10.5551/jat.56093

Table 2. Incidence of bleeding events in each stroke subtype group.

Large-artery atherosclerosis, %
Small-artery occlusion (lacunar), %
Acute stroke of other determined etiology, %
Stroke of undetermined etiology, %
Prasugrel Clopidogrel HR Prasugrel Clopidogrel HR Prasugrel Clopidogrel HR Prasugrel Clopidogrel HR
N = 553 N = 546 Estimate N = 583 N = 593 Estimate N = 35 N = 49 Estimate N = 714 N = 674 Estimate
[95% CI] [95% CI] [95% CI] [95% CI]
Life-threatening bleeding 0.9 1.5 0.61
[0.20, 1.87]
1.5 1.2 1.25
[0.46, 3.35]
0.0 2.0 - [-, -] 0.6 1.0 0.54
[0.16, 1.84]
Major bleeding 0.0 0.2 - [-, -] 0.2 0.0 - [-, -] 2.9 0.0 - [-, -] 0.0 0.4 - [-, -]
Clinically relevant bleeding 4.5 3.3 1.38
[0.75, 2.52]
6.0 5.4 1.07
[0.66, 1.73]
8.6 4.1 2.19
[0.37, 13.12]
4.9 4.6 1.07
[0.66, 1.74]
Life-threatening bleeding, major bleeding, and clinically relevant bleeding 5.4 4.9 1.10
[0.65, 1.85]
7.4 6.6 1.08
[0.70, 1.66]
8.6 6.1 1.44
[0.29, 7.16]
5.5 6.1 0.90
[0.58, 1.39]

CI = confidence interval, HR = haard ratio