Table 2. Incidence of bleeding events in each stroke subtype group.
Large-artery atherosclerosis, % |
Small-artery occlusion (lacunar), % |
Acute stroke of other determined etiology, % |
Stroke of undetermined etiology, % |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Prasugrel | Clopidogrel | HR | Prasugrel | Clopidogrel | HR | Prasugrel | Clopidogrel | HR | Prasugrel | Clopidogrel | HR | |
N = 553 | N = 546 | Estimate | N = 583 | N = 593 | Estimate | N = 35 | N = 49 | Estimate | N = 714 | N = 674 | Estimate | |
[95% CI] | [95% CI] | [95% CI] | [95% CI] | |||||||||
Life-threatening bleeding | 0.9 | 1.5 | 0.61 [0.20, 1.87] |
1.5 | 1.2 | 1.25 [0.46, 3.35] |
0.0 | 2.0 | - [-, -] | 0.6 | 1.0 | 0.54 [0.16, 1.84] |
Major bleeding | 0.0 | 0.2 | - [-, -] | 0.2 | 0.0 | - [-, -] | 2.9 | 0.0 | - [-, -] | 0.0 | 0.4 | - [-, -] |
Clinically relevant bleeding | 4.5 | 3.3 | 1.38 [0.75, 2.52] |
6.0 | 5.4 | 1.07 [0.66, 1.73] |
8.6 | 4.1 | 2.19 [0.37, 13.12] |
4.9 | 4.6 | 1.07 [0.66, 1.74] |
Life-threatening bleeding, major bleeding, and clinically relevant bleeding | 5.4 | 4.9 | 1.10 [0.65, 1.85] |
7.4 | 6.6 | 1.08 [0.70, 1.66] |
8.6 | 6.1 | 1.44 [0.29, 7.16] |
5.5 | 6.1 | 0.90 [0.58, 1.39] |
CI = confidence interval, HR = haard ratio