Table 1.
Type of DAMPs in septic AKI.
| Location | Name | Interaction | References | |
|---|---|---|---|---|
| Kidney, non-specific | Nucleus | HMGB1 | TLR2/TLR4 CXCL12 | (73) (74) (76) |
| Histones | TLR2/TLR4 | (80) (81) (82) |
||
| Mitochondrial | mtDNA | TLR9 | (90) | |
| Extracellular | Decorin | TLR2/TLR4 | (87) | |
| Biglycan | TLR2/TLR4 P2X receptor | (83) (84) (85) (86) |
||
| Kidney, specific | Uromodulin | TLR4 | (92) |
Several DAMPs (Damage associated molecular patterns) of interest which promote sepsis acute kidney injury and relevant reference. HMGB1, High mobility group box 1; TLR, Toll-like receptor; mtDNA, mitochondrial DNA.