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. 2021 Mar 1;12:616507. doi: 10.3389/fgene.2021.616507

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Copyright © 2021 Tan, Zhu, Tang, Liu, Wanggou, Cao, Xin, Zhou, Zhan, Wu, Guo, Jiang, Zhao, Ren, Jiang and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mRNAsi-related genes could classify glioma into two groups by consensus clustering of TCGA dataset. (A) Cumulative distribution function (CDF) for k = 2 to k = 6. (B) Relative change in area under the CDF curve according to different k values. (C) Consensus clustering matrix of 583 samples from TCGA dataset for k = 2. (D) Heatmap of two clusters defined by the expression of mRNAsi genes. (E) Survival analysis of patients in the S1 group and S2 group in TCGA cohort. (F) Protein-protein interaction (PPI) network of the mRNAsi-related genes.