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. 2021 Mar 1;12:602160. doi: 10.3389/fgene.2021.602160

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Copyright © 2021 Liu, Geng, Lin, Zhao and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Cox proportional hazard model of ERBBs and six tumor-infiltrating immune cells in cutaneous melanoma (TIMER). (A) ERBB1 (EGFR) expression had noteworthy positive interrelated to infiltrating levels of CD4⁺ T cells, Macrophage, and Neutrophil. (B) ERBB2 was negatively correlative with the infiltration of B cells and CD8⁺ T cells but positively related to the infiltration of CD4⁺ T cells. (C) ERBB3 expression was positively associated with the infiltration of CD8⁺ T cells, CD4⁺ T cells, and Neutrophil. (D) ERBB4 expression was positively related to the infiltration of CD8⁺ T cells and neutrophils. The correlation between ERBBs and immune cells were used to analyze by Spearman’s correlation.