TABLE 2.
Correlation analysis between ERBBs and related markers of immune cells.
| Description | Gene markers | SKCM |
|||||||
| Purity |
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| ERBB1 |
ERBB2 |
ERBB3 |
ERBB4 |
||||||
| Cor | P | Cor | P | Cor | P | Cor | P | ||
| CD8+ T cell | CD8A | −0.053 | 2.62e-1 | −0.045 | 3.37e-01 | 0.133 | ** | 0.1 | * |
| CD8B | −0.078 | 9.74e-02 | −0.066 | 1.61e-01 | 0.086 | 6.62e-02 | 0.086 | 6.65e-02 | |
| T cell (general) | CD3D | −0.041 | 3.85e-01 | −0.088 | 5.90e-02 | 0.047 | 3.18e-01 | 0.08 | 8.59e-02 |
| CD3E | −0.029 | 5.32e-01 | −0.05 | 2.85e-01 | 0.047 | 3.11e-01 | 0.087 | 6.26e-02 | |
| CD2 | −0.015 | 7.48e-01 | −0.066 | 1.58e-01 | 0.102 | * | 0.107 | * | |
| B cell | CD19 | −0.007 | 8.85e-01 | −0.117 | * | 0.021 | 6.57e-01 | 0.155 | *** |
| CD79A | −0.094 | * | −0.111 | * | 0 | 9.98e-01 | 0.13 | ** | |
| Monocyte | CD86 | 0.072 | 1.22e-01 | −0.001 | 9.85e-01 | 0.062 | 1.85e-01 | 0.151 | ** |
| CD115 | 0.175 | *** | 0.102 | * | 0.08 | 8.57e-02 | 0.123 | ** | |
| TAM | CCL2 | 0.128 | ** | 0.009 | 8.52e-01 | −0.021 | 6.57e-01 | 0.11 | * |
| CD68 | −0.015 | 7.50e-01 | −0.041 | 3.77e-01 | −0.147 | ** | −0.054 | 2.49e-01 | |
| IL10 | 0.063 | 1.77e-01 | −0.016 | 7.27e-01 | 0.002 | 9.63e-01 | 0.056 | 2.31e-01 | |
| M1 Macrophage | iNOS | −0.205 | *** | 0.012 | 8.01e-01 | 0.044 | 3.43e-01 | −0.006 | 8.92e-01 |
| IRF5 | 0.073 | 1.21e-01 | 0.033 | 4.86e-01 | −0.076 | 1.07e-01 | −0.006 | 8.94e-01 | |
| COX2 | 0.215 | *** | 0.043 | 3.57e-01 | −0.006 | 8.94e-01 | 0.127 | ** | |
| M2 Macrophage | CD163 | 0.124 | ** | 0.045 | 3.40e-01 | 0.047 | 3.17e-01 | 0.148 | ** |
| VSIG4 | 0.063 | 1.77e-01 | 0.073 | 1.20e-01 | 0.05 | 2.84e-01 | 0.106 | * | |
| MS4A4A | 0.091 | 5.30e-02 | −0.007 | 8.74e-01 | 0.044 | 3.43e-01 | 0.139 | ** | |
| Neutrophils | CD66b | 0.049 | 2.94e-01 | −0.062 | 1.88e-01 | −0.116 | * | 0 | 9.94e-01 |
| CD11b | 0.104 | * | 0.062 | 1.84e-01 | 0.085 | 7.00e-02 | 0.102 | * | |
| CCR7 | 0.042 | 3.73e-01 | −0.076 | 1.07e-01 | 0.06 | 2.01e-01 | 0.1 | * | |
| Dendritic cell | HLA-DPB1 | 0.036 | 4.42e-01 | 0.113 | * | 0.107 | * | 0.052 | 2.65e-01 |
| HLA-DQB1 | 0.05 | 2.91e-01 | 0.039 | 4.11e-01 | 0.066 | 1.58e-01 | 0.068 | 1.46e-01 | |
| HLA-DRA | 0.046 | 3.26e-01 | 0.055 | 2.42e-01 | 0.115 | * | 0.084 | 7.19e-02 | |
| HLA-DPA1 | 0.027 | 5.67e-01 | 0.1 | * | 0.119 | * | 0.064 | 1.69e-01 | |
| BDCA-1 | 0.214 | *** | −0.01 | 8.26e-01 | 0.084 | 7.32e-02 | 0.162 | *** | |
| BDCA-4 | 0.434 | *** | 0.079 | 9.06e-02 | 0.053 | 2.59e-01 | 0.182 | *** | |
| CD11c | 0.011 | 8.17e-01 | −0.029 | 5.41e-01 | −0.059 | 208e-01 | 0.067 | 1.54e-01 | |
| Th1 | T-bet | −0.017 | 7.22e-01 | −0.06 | 2.02e-01 | 0.066 | 1.56e-01 | 0.121 | ** |
| STAT4 | −0.114 | * | 0.007 | 8.83e-01 | 0.181 | *** | 0.172 | *** | |
| STAT1 | −0.01 | 8.25e-01 | 0.043 | 3.56e-01 | 0.242 | *** | 0.107 | * | |
| IFN-γ | −0.068 | 1.45e-01 | −0.102 | * | 0.107 | * | 0.084 | 7.22e-02 | |
| TNF-α | 0.106 | * | 0.026 | 5.73e-01 | 0.046 | 3.25e-01 | 0.026 | 5.85e-01 | |
| Th2 | GATA3 | 0.327 | *** | 0.089 | 5.76e-02 | 0.015 | 7.42e-01 | 0.144 | ** |
| STAT6 | 0.141 | ** | 0.228 | 8.32e-07 | 0.337 | *** | 0.069 | 1.40e-01 | |
| STAT5A | −0.045 | 3.33e-01 | 0.159 | *** | 0.326 | *** | 0.103 | ** | |
| IL13 | 0.049 | 2.93e-01 | −0.052 | 2.68e-01 | −0.018 | 7.06e-01 | 0.007 | 8.80e-01 | |
| Tfh | BCL6 | 0.255 | *** | 0.158 | *** | 0.023 | 6.27e-01 | 0.158 | *** |
| IL21 | 0.08 | 8.66e-02 | 0.077 | 1.01e-01 | 0.057 | 2.27e-01 | 0.179 | *** | |
| Th17 | STAT3 | 0.282 | *** | 0.331 | *** | 0.29 | *** | 0.195 | *** |
| IL17A | 0.034 | 4.63e-01 | 0.079 | 9.02e-02 | 0.003 | 9.50e-01 | −0.037 | 4.28e-01 | |
| Treg | FOXP3 | 0.072 | 1.22e-01 | −0.013 | 7.76e-01 | −0.004 | 9.28e-01 | 0.044 | 3.44e-01 |
| CCR8 | 0.138 | ** | −0.039 | 4.09e-01 | 0.145 | ** | 0.133 | ** | |
| STAT5B | 0.174 | *** | 0.235 | *** | 0.331 | *** | 0.174 | *** | |
| TGFβ | 0.276 | *** | 0.177 | *** | −0.1 | * | 0.048 | 3.02e-01 | |
| T cell exhaustion | PD-1 | −0.099 | * | −0.048 | 3.01e-01 | 0.065 | 1.66e-01 | 0.063 | 1.78e-01 |
| CTLA4 | −0.086 | 6.49e-02 | −0.171 | *** | −0.076 | 1.05e-01 | 0.071 | 1.29e-01 | |
| LAG3 | −0.129 | ** | −0.034 | 4.65e-01 | 0.058 | 2.19e-01 | 0.053 | 2.59e-01 | |
| TIM-3 | 0.036 | 4.42e-01 | 0 | 9.94e-01 | 0.069 | 1.41e-01 | 0.118 | ** | |
| GZMB | −0.097 | * | −0.132 | ** | −0.011 | 8.17e-01 | 0.016 | 7.31e-01 | |
TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R-value of Spearman’s correlation; Purity, correlation adjusted by purity. *P < 0.05, **P < 0.01, ***P < 0.001.