Table 1.
Current status of vaccines against H. influenzae, N. meningitidis, S. pneumoniae and S. agalactiae.
| Bacterial species | Licensed vaccines and targets | Vaccines in clinical development | References |
|---|---|---|---|
| Haemophilus influenzae | ActHIB, Sanofi Pasteur Hib (PRP-T) Hiberix, GSK Vaccines Hib (PRP-T) PedvaxHIB, Merck Hib (PRP-OMP) Combination vaccines: Pentacel/Pentaxim, Sanofi Pasteur (DTaP, IPV, Hib [PRP-T]) Hexaxim/Hexyon, Sanofi Pasteur (DTaP, IPV, Hib [PRP-T], HBV) Vaxelis, Sanofi (DTaP, IPV, Hib [PRP-OMP], HBV) Infanrix Penta, GSK Vaccines (DTaP, IPV, Hib [PRP-T]) Infanrix Hexa, GSK Vaccines (DTaP, IPV, Hib [PRP-T], HBV) Menitorix, GSK Vaccines (Hib [PRP-T], MenC [PsC-T]) Menhibrix, GSK Vaccines (Hib [PRP-T], MenCY [PsC-T, PsY-T]) |
[84] | |
| Neisseria meningitidis |
Polysaccharide vaccines: Menomune, Sanofi Pasteur (PsA, PsC, PsW, PsY) Mencevax/ACWYVax, Pfizer (PsA, PsC, PsW, PsY) NmVac4-A/C/Y/W-135, JN-International Medical Corporation (ACWY) |
[1, 85] | |
|
Polysaccharide-protein conjugate vaccines: Menactra, Sanofi Pasteur (PsA-D, PsC-D, PsW-D, PsY-D) Menveo, GSK Vaccines (PsA-CRM197, PsC-CRM197, PsW-CRM197, PsT-CRM197) Mejugate, GSK Vaccines (PsC-CRM197) Nimenrix, Pfizer (PsA-T, PsC-T, PsW-T, PsY-T) NeisVac-C, Pfizer (PsC-T) MenAfriVac, Serum Institute of India (PsA-T) Menitorix, GSK Vaccines (Hib [PRP-T], MenC [PsC-T]) Menhibrix, GSK Vaccines (Hib [PRP-T], MenCY [PsC-T, PsY-T]) MenQuadfi, Sanofi Pasteur (MenACWY, [PRP-T]) |
Polysaccharide-protein conjugate vaccines: NmCV-5, Serum Institute of India (PsA-T, PsC—CRM197, PsW-CRM197, PsX-T, PsY-CRM197) |
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|
Outer membrane vesicle vaccines: VA-MENGOC-BC, Finlay Institute Vaccine, Cuba (CU385/83 B:4:P1.19, 15) (no longer in production) |
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|
Protein-based vaccines: Bexsero (4CMenB), GSK Vaccines (NZ98/254 OMV, FHbp, NadA, NHPA) Trumenba, Pfizer (bivalent FHbp) |
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| Streptococcus pneumoniae |
Polysaccharide vaccine: Pneumovax®23 - serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9 V, 9 N, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, 33F |
[86] | |
|
Polysaccharide-protein conjugate vaccines: Synflorix™, GSK Vaccines (10-valent) – serotypes: 1, 4, 5, 6B, 7F, 9 V, 14, 18C, 19F, 23F Prevenar/Prevnar®, Pfizer (13-valent) – serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 14, 18C, 19A, 19F, 23F Pneumosil, Serum Institute of India (10-valent) – serotypes: 1, 5, 6A, 6B, 7F, 9 V, 14, 19A, 19F, 23F |
Polysaccharide-protein conjugate vaccines in Phase 3 clinical trials: V114, MSD (15-valent) – serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9 V, 14, 18C, 19A, 19F, 22F, 23F, and 33F 20vPnC, Pfizer (20-valent) – serotypes: 1, 3, 4, 5, 6A, 6B, 7F, 8, 9 V, 10A, 11A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, 33F |
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| Streptococcus agalactiae | Licenced vaccines not yet available | Pfizer: Up to 6-valent vaccine recruiting for trials Minervax: N-terminal domains of the Rib and AlphaC surface protein vaccines |
[7] |