TABLE 2.
Associations between whole body fat free mass/whole body fat mass and risk of gastric cancer
| Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|
| Case/person‐years | Hazard Ratio (95% Confidence Interval) | Case/person‐years | Hazard Ratio (95% Confidence Interval) | |||||
| Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |||
|
Whole body fat‐free mass Quartiles | ||||||||
| Quartile 1 | 46/346049 | 1.00(Reference) | 1.00(Reference) | 1.00(Reference) | 23/410209 | 1.00(Reference) | 1.00(Reference) | 1.00(Reference) |
| Quartile 2 | 67/345128 | 1.62(1.11, 2.36) a | 1.72(1.16, 2.56) b | 1.64(1.09, 2.46) a | 22/416519 | 1.05(0.59, 1.89) | 1.07(0.59, 1.96) | 1.26(0.68, 2.34) |
| Quartile 3 | 58/353914 | 1.49(1.01, 2.20) a | 1.60(1.04, 2.45) a | 1.49(0.94, 2.35) | 24/409769 | 1.26(0.71, 2.23) | 1.28(0.70, 2.35) | 1.73(0.89, 3.36) |
| Quartile 4 | 58/349725 | 1.76(1.19, 2.61) b | 1.86(1.17, 2.96) b | 1.70(1.01, 2.89) a | 28/419038 | 1.59(0.91, 2.77) | 1.52(0.81, 2.84) | 2.47(1.15, 5.32) a |
| P‐trend | 0.01 | 0.02 | 0.12 | 0.08 | 0.16 | 0.02 | ||
|
Continuous per 5‐unit increase Whole body fat mass Quartiles |
1.11(1.02, 1.21) a | 1.11(1.00, 1.23) | 1.09(0.95, 1.24) | 1.23(1.02, 1.49) a | 1.21(0.98, 1.50) | 1.52(1.13, 2.03) b | ||
| Quartile 1 | 37/349876 | 1.00(Reference) | 1.00(Reference) | 1.00(Reference) | 23/414586 | 1.00(Reference) | 1.00(Reference) | 1.00(Reference) |
| Quartile 2 | 55/348536 | 1.36(0.89, 2.06) | 1.36(0.90, 2.07) | 1.27(0.83, 1.94) | 25/413692 | 0.95(0.54, 1.67) | 0.91(0.52, 1.62) | 0.83(0.46, 1.48) |
| Quartile 3 | 63/347688 | 1.50(1.00, 2.25) a | 1.45(0.96, 2.19) | 1.28(0.84, 1.97) | 23/413348 | 0.82(0.46, 1.47) | 0.75(0.41, 1.35) | 0.59(0.31, 1.11) |
| Quartile 4 | 74/348715 | 1.74(1.17, 2.59) a | 1.53(1.01, 2.32) a | 1.26(0.79, 2.00) | 26/413908 | 0.98(0.56, 1.73) | 0.78(0.43, 1.43) | 0.47(0.22, 0.98) |
| P‐trend | 0.006 | 0.07 | 0.43 | 0.93 | 0.38 | 0.03 | ||
| Continuous per 5‐unit increase | 1.11(1.03, 1.19) | 1.07(0.99, 1.16) | 1.03(0.93, 1.14) | 1.03(0.93, 1.14) | 0.99(0.88, 1.10) | 0.86(0.74, 0.99) | ||
Model 1: Age (37–49, 50–59, or ≥75 years) stratified model
Model 2: Additionally adjusted for ethnic (white, non‐white), index of multiple deprivation (fifth), alcohol consumption (daily or almost daily, three or four times a week, once or twice a week, one to three times a month, special occasions only, never, or unknown/missing), smoking status (never smoker, previous smoker, or current smoker), physical activity (low, moderate, or high), fruit and vegetable intake (≥5 portions or <5 portions), diabetes (yes or no), height (75–159, 160–169,170–179 or 180–209 cm).
Model 3: Additionally, mutually adjusted for fat free mass and fat mass.
0.01 < p ≤ 0.05
0.001 < p ≤ 0.005.