TABLE 3.
Risk of gastric cancer according to body mass index and waist circumference
| Males | Females | |||||
|---|---|---|---|---|---|---|
|
Case/ person‐years |
Hazard Ratio (95% Confidence Interval) |
Case/ person‐years |
Hazard Ratio (95% Confidence Interval) | |||
| Model 1 | Model 2 | Model 1 | Model 2 | |||
|
Body mass index Quartiles | ||||||
| Quartile 1 | 38/349079 | 1.00(Reference) | 1.00(Reference) | 24/414594 | 1.00(Reference) | 1.00(Reference) |
| Quartile 2 | 56/348681 | 1.41(0.93, 2.13) | 1.42(0.87, 2.32) | 23/413926 | 0.85(0.48, 1.51) | 0.98(0.56, 1.72) |
| Quartile 3 | 69/348241 | 1.73(1.16, 2.57) b | 1.91(1.19, 3.04) b | 22/413857 | 0.75(0.42, 1.35) | 0.91(0.51, 1.63) |
| Quartile 4 | 66/347723 | 1.69(1.13, 2.51) b | 1.74(1.07, 2.84) a | 28/412772 | 1.01(0.59, 1.75) | 0.90(0.51, 1.61) |
| P‐trend | 0.01 | 0.09 | 0.87 | 0.51 | ||
|
Continuous per 5‐unit increase Waist circumference Quartiles |
1.25(1.08, 1.44) a | 1.17(1.01, 1.37) a | 1.12(0.93, 1.35) | 1.03(0.84, 1.26) | ||
| Quartile 1 | 27/313565 | 1.00(Reference) | 1.00(Reference) | 20/367629 | 1.00(Reference) | 1.00(Reference) |
| Quartile 2 | 52/364109 | 1.52(0.96, 2.42) | 2.82(0.67, 11.78) | 24/440833 | 0.87(0.48, 1.58) | 0.99(0.6, 1.62) |
| Quartile 3 | 62/337724 | 1.85(1.18, 2.91) b | 4.09(1.00, 16.70) a | 25/415978 | 0.88(0.49, 1.59) | 0.50(0.25, 1.04) |
| Quartile 4 | 88/379305 | 2.27(1.47, 3.50) c | 4.65(1.14, 18.91) b | 28/430853 | 0.95(0.53, 1.69) | 1.36(0.75, 2.45) |
| P‐trend | <0.001 | <0.001 | 0.96 | 0.37 | ||
| Continuous per 5‐unit increase | 1.11(1.05, 1.17) c | 1.09(1.02, 1.15) b | 1.05(0.97, 1.13) | 1.01(0.93, 1.10) | ||
Model 1: Age (37–49, 50–59, or ≥75 years) stratified model;
Model 2: Additionally adjusted for ethnic (white, non‐white), index of multiple deprivation (fifth), alcohol consumption (daily or almost daily, three or four times a week, once or twice a week, one to three times a month, special occasions only, never, or unknown/missing), smoking status (never smoker, previous smoker, or current smoker), physical activity (low, moderate, or high), fruit and vegetable intake (≥5 portions or <5 portions), diabetes (yes or no), height (75–159, 160–169,170–179 or 180–209 cm), NSAIDS use (yes or no), and family history of cancer (yes or no).
0.01 < p ≤ 0.05
0.001 < p ≤ 0.005
p ≤ 0.001.