TABLE 4.
Associations between anthropometric measurements and risk of gastric cardia adenocarcinoma and non‐gastric cardia adenocarcinoma.
| Gastric cardia adenocarcinoma | Non‐gastric cardia adenocarcinoma | |||
|---|---|---|---|---|
| Case/person‐years | HR (95% CI) | Case/person‐years | HR (95% CI) | |
|
Whole body fat‐free mass Quartiles | ||||
| Quartile 1 | 11/755771 | 1.00(Reference) | 30/755771 | 1.00(Reference) |
| Quartile 2 | 14/772667 | 0.91(0.39, 2.16) | 38/772667 | 1.74(1.02, 2.98) a |
| Quartile 3 | 46/759315 | 1.02(0.33, 3.14) | 55/759315 | 2.04(0.94, 4.46) |
| Quartile 4 | 64/762598 | 1.23(0.35, 4.27) | 68/762598 | 3.31(1.32, 8.28) b |
| P value for trend | 0.46 | 0.01 | ||
|
Continuous per 5‐unit increase Whole body fat mass Quartiles |
1.06(0.88, 1.27) | 1.23(1.05, 1.45) a | ||
| Quartile 1 | 28/751992 | 1.00(Reference) | 40/751992 | 1.00(Reference) |
| Quartile 2 | 31/771785 | 1.09(0.65, 1.83) | 56/771785 | 1.17(0.77, 1.77) |
| Quartile 3 | 41/758246 | 1.48(0.88, 2.47) | 49/758246 | 0.90(0.58, 1.41) |
| Quartile 4 | 35/768329 | 1.47(0.81, 2.66) | 46/768329 | 0.70(0.42, 1.17) |
| P value for trend | 0.15 | 0.12 | ||
|
Continuous per 5‐unit increase Body mass index Quartiles |
1.06(0.94, 1.21) | 0.92(0.83, 1.03) | ||
| Quartile 1 | 19/764601 | 1.00(Reference) | 31/764601 | 1.00(Reference) |
| Quartile 2 | 26/762934 | 1.01(0.56, 1.83) | 49/762934 | 1.27(0.81, 2.00) |
| Quartile 3 | 46/761072 | 1.58(0.92, 2.72) | 58/761072 | 1.33(0.85, 2.08) |
| Quartile 4 | 44/760267 | 1.62(0.92, 2.84) | 53/760267 | 1.14(0.71, 1.81) |
| P value for trend | 0.04 | 0.79 | ||
|
Continuous per 5‐unit increase Waist circumference Quartiles |
1.19(0.98, 1.44) | 1.07(0.92, 1.26) | ||
| Quartile 1 | 10/699360 | 1.00(Reference) | 25/699360 | 1.00(Reference) |
| Quartile 2 | 21/808173 | 0.97(0.44, 2.12) | 41/808173 | 1.04(0.62, 1.74) |
| Quartile 3 | 34/762488 | 1.16(0.54, 2.50) | 54/762488 | 1.16(0.69, 1.95) |
| Quartile 4 | 70/779975 | 1.96(0.92, 4.15) | 71/779975 | 1.23(0.72, 2.10) |
| P value for trend | 0.003 | 0.36 | ||
| Continuous per 5‐unit increase | 1.09(1.02, 1.18) a | 1.04(0.97, 1.1) | ||
HR, hazard ratio; CI, confidence interval.
The analyses were stratified by age (37–49, 50–59, or ≥75 years) and additionally adjusted for ethnic (white, non‐white), index of multiple deprivation (fifth), alcohol consumption (daily or almost daily, three or four times a week, once or twice a week, one to three times a month, special occasions only, never, or unknown/missing), smoking status (never smoker, previous smoker, or current smoker), physical activity (low, moderate, or high), fruit and vegetable intake (≥5 portions or <5 portions), diabetes (yes or no), height (75–159, 160–169,170–179 or 180–209 cm), NSAIDS use (yes or no), and family history of cancer (yes or no). For whole body fat‐free mass and whole body fat mass, mutually adjusted was applied.
0.01 < p ≤ 0.05
0.001 < p ≤ 0.005.