Table 2a.
Time to QFT conversion among previously QFT‐negative study participants, comparing APHIV to HIV‐youth (N = 380): crude and adjusted hazard ratios from Cox proportional hazards regression
| Crude HR (95% CI) | aHR (95% CI) 1 | |
|---|---|---|
| HIV infection: HIV positive versus HIV negative | 0.65 (0.39 to 1.09) | – |
| Effects of time‐varying HIV viral suppression on relative Hazard of QFT conversion among HIV+ versus HIV− youth | ||
| HIV negative (reference) | 1.00 | 1.00 |
| HIV positive, viral load ≤40 copies/mL | 0.75 (0.44 to 1.27) | 0.92 (0.52 to 1.62) |
| HIV positive, viral load >40, <1000 copies/mL | 0.59 (0.29 to 1.23) | 0.75 (0.35 to 1.62) |
| HIV positive, viral load ≥1000 copies/mL | 0.23 (0.07 to 0.79) | 0.29 (0.08 to 1.00) |
| Male versus female sex | 0.71 (0.46 to 1.11) | – |
| Age at study visit (time‐varying, per year increase) | 0.92 (0.81 to 1.05) | 0.86 (0.73 to 1.00) |
| Categories of age at study visit (time‐varying, in years) | ||
| <12 years (reference) | 1.00 | – |
| ≥12, <14 years | 1.55 (0.73 to 3.31) | – |
| ≥14, <16 years | 1.14 (0.52 to 2.52) | – |
| ≥16 years | 1.00 (0.39 to 2.56) | – |
| BMI categories (time‐varying) | ||
| Normal weight, ≥18, <25 kg/m2 (reference) | 1.00 | – |
| Underweight, <18 kg/m2 | 0.67 (0.41 to 1.10) | – |
| Overweight/obese, ≥25 kg/m2 | 0.87 (0.44 to 1.72) | – |
| Tanner staging at study visit (time‐varying) | ||
| Stage I (pre‐adolescent), reference | 1.00 | 1.00 |
| Stage II to IV (adolescent) | 1.02 (0.56 to 1.84) | 1.34 (0.71 to 2.52) |
| Stage V (mature) | 1.46 (0.73 to 2.90) | 2.40 (1.06 to 5.42) |
| Known TB contact at enrolment (yes vs. no) | 1.78 (0.33 to 5.65) | – |
aHR, adjusted hazard ratio; CD, cluster of differentiation; CI, confidence intervals; HIV, human immunodeficiency virus; HR, hazard ratio; QFT, interferon gamma release assay (QuantiFERON‐TB).
Bold indicates statistically significant values.
1
Multivariable model adjusted for all variables with adjusted estimates shown as well as baseline measures of relative poverty.