TABLE 1.
Top enriched terms from KEGG pathway enrichment of differentially expressed genes shown as PD‐L1KO/control ranked by q‐value
| PD‐L1KO MB49 clone 18/Ctrl MB49 | ||||||
|---|---|---|---|---|---|---|
| ID | Description | GeneRatio | BgRatio | p value | p adjust | q value |
| mmu04512 | ECM‐receptor interaction | 22/954 | 88/8913 | 1.06E−04 | 2.62E−02 | 2.27E−02 |
| mmu04010 | MAPK signaling pathway | 52/954 | 294/8913 | 1.66E−04 | 2.62E−02 | 2.27E−02 |
| PD‐L1KO RT4 clone 2/Ctrl RT4 | ||||||
|---|---|---|---|---|---|---|
| ID | Description | GeneRatio | BgRatio | p value | p adjust | q value |
| hsa04668 | TNF signaling pathway | 31/1023 | 112/8077 | 1.44E−05 | 4.59E−03 | 3.95E−03 |
| hsa05133 | Pertussis | 22/1023 | 76/8077 | 1.21E−04 | 1.92E−02 | 1.65E−02 |
| hsa04151 | PI3 K‐Akt signaling pathway | 66/1023 | 354/8077 | 6.47E−04 | 4.66E−02 | 4.01E−02 |
| hsa05142 | Chagas disease | 25/1023 | 102/8077 | 7.33E−04 | 4.66E−02 | 4.01E−02 |
| hsa05165 | Human papillomavirus infection | 62/1023 | 331/8077 | 8.28E−04 | 4.66E−02 | 4.01E−02 |
| hsa05222 | Small cell lung cancer | 23/1023 | 92/8077 | 8.80E−04 | 4.66E−02 | 4.01E−02 |
Abbreviations: ECM, extracellular matrix; MAPK, mitogen‐activated protein kinase; TNF, tumor necrosis alpha; PI3 K, phosphoinositol 3‐kinase.