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Scoparone inhibits Ang II‐induced cardiac fibroblasts differentiation and collagen synthesis by suppressing Rac1. NRCFs were treated with Ang II (1 μmol/L), scoparone (SCO, 50 μmol/L), control or RAC1 overexpression adenovirus (10 moi) for 48 h. A, Immunofluorescent staining of α‐SMA (n = 3). B, Western blot of α‐SMA, CTGF, collagen I and collagen III (n = 3). *P < 0.05 vs control group; # P < 0.05 vs Ang II group; † P < 0.05 vs Ang II + SCO group
