Figure 3.
Sensitivity analysis forest plots assessing interaction between cigarette smoking and cannabis use and their effects on inpatient opioid dose exposure in IVMMEs/day. Addition of cigarette smoking to primary analysis model: preadmission cannabis use coefficient = 12.0; 95% CI, 2.1-21.9; preadmission opioid use coefficient = 22.5; 95% CI, 17.2-27.8; first pain score coefficient = 1.4; 95% CI, 0.7-2.0; cigarette smoking coefficient = –0.2; 95% CI, –8.2 to 7.9. Replacement of cannabis use with cigarette smoking in primary analysis model: preadmission opioid use coefficient = 22.6; 95% CI, 17.2-28.0; first pain score coefficient = 1.4; 95% CI, 0.7-2.1; cigarette smoking coefficient = 2.6; 95% CI, –5.1 to 10.4. Nonsignificant covariates removed via stepwise backward elimination using P < 0.05.