TABLE 2.

Epigenome-wide associations between genome-wide DNA methylation and diffusing capacity of the lung for carbon monoxide (D_LCO)/alveolar volume (V_A)

Model	CpG	Chromosome	Position	Gene	RS			FHS
					Effect estimate	Standard error	FDR	Effect estimate	Standard error	FDR
M1	cg05575921	5	373 378	AHRR	0.065	0.012	0.017	0.037	0.0055	8.72×10−6
M2	cg05575921	5	373 378	AHRR	0.064	0.012	0.047	0.040	0.0057	1.56×10−6
M2	cg05951221	2	233 284 402	ALPG#	0.049	0.0093	0.047	0.030	0.0051	3.60×10−4

RS: Rotterdam Study (the “discovery panel”); FHS: Framingham Heart Study (the “replication panel”); FDR: false discovery rate; M1: model adjusted for age, sex, current smoking, former smoking, white blood cell count and batch effect; M2: model adjusted for age, sex, current smoking, former smoking, weight, height, white blood cell count and batch effect; ^#: closest gene (distance >8 Kbp).