Table 3.

Expression level modification of proteins involved in iodine transport and their organization in thyroid cancer compared to normal tissue. ND: not detected; PM: plasma membrane; DTC: differentiated thyroid cancer; mDTC: metastasis of DTC; PDTC: poorly differentiated thyroid cancer; ATC: anaplastic thyroid cancer.

	DTC	mDTC	PDTC and ATC
TSH-R	↓	↓↓↓	↓↓↓
NIS	↓ = (PM/cytoplasm)	↓↓ (PM/cytoplasm)	ND
Pendrin	↓↓		ND
TG	↓	↓↓↓	↓↓↓↓
TPO	↓ (PM/cytoplasm)	↓↓ (PM/cytoplasm)	ND
Duox2	= (PM/cytoplasm)	↓	ND
GLUT1	= or slightly ↑	↑↑	↑↑

↓: slight decrease, ↓↓: decrease, ↓↓↓: high decrease, ↓↓↓↓: Very high decrease, but still measurable, = unaltered.