Table 2.

Potential mechanisms of effects of EPA and DHA on endothelium.

Number in Figure 3	Haemostasis Component	Potential Mechanism	Effect	Strength of Evidence	Reference
1	Endothelial synthase of nitric oxide (eNOS)	Higher production of NO	Vasodilatation effect	High	Łacheta, Yamagata [39,40]
2	Adhesive receptors	Decrease of expression of adhesive molecules (VCAM, ICAM); reduced expression of tumor necrosis factor alpha (TNF-α) and PAI-1		High	Wang, Liu [41,42]
2a	Protein synthesis	Decreased synthesis of endothelin-1	Anticoagulation effects	Moderate	Yamagata [40]
3	Receptor for t-PA	Higher level of t-PA	Fibrinolytic effects	Low	Din [43]
4	Receptor for oxLDL	Regulation of expression of the receptor for oxLDL	Inhibition of formation of oxidized LDL	High	Chen [44]
5	Inhibition of microparticles formation	Lower expression of tissue factor	Reduction of oxidative stress, inhibition of thrombin generation	Low	Qureshi [45]