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The schema of mechanism of OIIRR. Abbreviations; OIIRR = orthodontically induced inflammatory root resorption, hPDL cells = Human periodontal ligament cells, PGE2 = prostaglandin E2, IL-1 = interleukin 1, IL-6 = interleukin 6, IL-17 = interleukin 17, RANKL = Receptor activator of nuclear factor ligand, RANK = Receptor activator of nuclear factor, TNF-alpha = tumor necrosis factor-alpha.
