Table 1.

Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities of compounds 6aa–ch. IC₅₀, half maximal inhibitory concentration; Clau F, Claulansine F.

Compound	IC50 (μM) (a) or Inhibition Rate (%) in 100 μM
	AChE	BuChE
6aa	51.92 ± 2.24	22.86 ± 1.14
6ab	36.16 ± 0.31%	35.93 ± 5.13
6ac	50.93 ± 2.76%	34.26 ± 0.69
6ad	42.46 ± 6.12%	38.83 ± 2.48
6ae	20.43 ± 7.35%	69.13 ± 8.51
6af	34.20 ± 10.65%	24.52 ± 1.94
6ag	36.77 ± 1.25%	26.38 ± 4.51
6ah	40.05 ± 1.40%	18.02 ± 2.27
6ba	4.62 ± 0.28	12.27 ± 0.66
6bb	4.08 ± 0.12	5.63 ± 0.31
6bc	4.26 ± 0.22	19.01 ± 0.94
6bd	4.34 ± 0.46	5.46 ± 0.61
6be	1.69 ± 0.00	6.36 ± 1.21
6bf	1.63 ± 0.30	12.15 ± 0.76
6bg	27.72 ± 5.15	74.86 ± 3.21
6bh	23.60 ± 8.31	31.52 ± 3.88
6bi	58.36 ± 1.79	32.81 ± 0.50
6bj	91.13 ± 4.41	37.57 ± 0.56
6ca	9.00 ± 0.86	23.37 ± 0.95
6cb	10.67 ± 0.20	19.12 ± 2.04
6cc	14.30 ± 0.36	33.82 ± 0.51
6cd	16.96 ± 1.51	17.34 ± 4.82
6ce	41.70 ± 1.22	26.39 ± 1.40
6cf	54.82 ± 7.96	18.05 ± 3.35
6cg	72.97 ± 1.93	26.75 ± 1.76
6ch	24.56 ± 2.10	24.17 ± 4.78
Donepezil	0.17 ± 0.04	4.20 ± 0.48
Clau F	28.25 ± 2.11%	64.32 ± 7.52
CZ-7	32.54 ± 6.52%	59.54 ± 5.62