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. 2021 Feb 28;22(5):2440. doi: 10.3390/ijms22052440

Figure 3.

Figure 3

The VP3.15-treated mice preserve the optic nerve from myelin loss and axonal damage; (a–f): Detailed views of the optic nerve of vehicle (a–c) and VP3.15-treated mice (d–f), labelled for MBP (red), NFH (grey), and nuclei (Hoechst staining; blue); (g,h): Histograms showing a significant increase in the percentage of both MBP+ (g) and NFH+ (h) area in the VP3.15-treated compared to the vehicle-treated mice. Scale bar represents 50 µm in a–f. Abbreviations: MBP = myelin basic protein; NFH = neurofilament heavy. Results of Student’s t-test are represented as: ** p < 0.01; *** p < 0.001. EAE-VEH: n = 7; EAE-VP3.15: n = 10.