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. 2021 Feb 28;22(5):2440. doi: 10.3390/ijms22052440

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of VP3.15 on Iba-1⁺ in spinal cord and optic nerve; (A–D): Detailed views of the optic nerve of vehicle (A) and VP 3.15-treated mice (B) and the spinal cord of vehicle (C) and VP3.15-treated mice (D), labelled for Iba-1⁺ cells (green). Arrows point to amoeboid microglia cells and asterisks mark stellated-shaped microglial cells; (E,F): Stacked histograms of the spinal cord (E) and optic nerve (F) content in microglia. In both cases, whereas the ramified microglia remain constant in the EAE-VP3.15 and the EAE-VEH group, the proportion of a stellated-shaped and amoeboid microglia is the opposite, being higher in the former. Scale bar represents 50 µm in A–D. EAE-VEH: n = 7; EAE-VP3.15: n = 10.