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. 2021 Feb 27;22(5):2397. doi: 10.3390/ijms22052397

Figure 1.

Figure 1

Effects of JMV2959 on tetrahydrocannabinol (THC)-induced conditioned place preference (CPP) in rats. In graph (A), JMV2959 (0, 1, 3 mg/kg i.p.) was administered in a single dose 20 min before the final testing after 8 days of conditioning with THC (0.3 mg/kg i.p.) (saline n = 11; JMV2959 groups n = 8; means ± SEM). In graph (B), JMV2959 (0, 1, 3 mg/kg i.p.) was administered repeatedly during the 8 days conditioning together with THC (0.3 mg/kg i.p.) (saline n = 10; JMV2959 groups n = 9; means ± SEM). The results are presented as follows: Saline + THC (open bar), JMV2959 1 mg/kg + THC (striped bar), JMV2959 3 mg/kg + THC (filled bar). CPP was calculated as the difference in percentage of total (1200 s) time spent in the THC-paired (i.e., least preferred) compartment during the post-conditioning and/minus the pre-conditioning session. The effects of JMV2959 pretreatments in comparison to the saline group are expressed as # p < 0.05, ## p < 0.01, ### p < 0.001. The results are presented as group means with 95% confidence intervals.