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. 2021 Feb 27;22(5):2397. doi: 10.3390/ijms22052397

Figure 2.

Figure 2

Effects of JMV2959 on the THC-induced behavioral changes in rats in the LABORAS cage. JMV2959 (0, 1, 3 mg/kg i.p.) was administered immediately before placing the rats into the cage and after 20 min of habituation, a stimulatory THC dose 0.1 mg/kg or saline was administered intraperitoneally. After another 20 min of habituation, behavior monitoring started and lasted for 20 min (20–40 min after THC administration). Changes in locomotion duration (A), rear duration (B), immobility duration (C), distance traveled (D), and average speed overall (E) are illustrated as follows: saline + vehicle (open bar) (n = 9), saline + THC (filled bar) (n = 7),1 mg/kg + THC (vertically striped bar) (n = 8), JMV2959 3 mg/kg + THC (diamond bar) (n = 8), JMV2959 1mg/kg + vehicle (horizontally striped bar) (n = 4), JMV2959 3 mg/kg + vehicle (little arrows bar) (n = 8). The JMV2959 pretreatment effects in comparison to saline + THC group are expressed as # p < 0.05, ## p < 0.01, ### p < 0.001. Differences between groups in comparison to vehicle + saline group are expressed as ** p < 0.01, *** p < 0.001. The results are presented as group means with 95% confidence intervals.