Table 3.

Univariate and multivariate Cox proportional hazards analysis assessing PIK3CA mutation, EGFR amplification or CDKN2A mutation and clinicopathologic variables in OSCC patients. NSND = non-smoker and non-drinker; SD = smokers and/or drinker; LN = lymph node; PNI = perineural invasion; LVI = lymphovascular invasion; HR = hazard ratio, AHR = adjusted hazard ratio, CI = confidence interval; * p < 0.05.

	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p	AHR	95% CI	p
PIK3CA Mutation	2.0	1.0–3.9	0.050 *	1.4	0.7–2.9	0.303
Male vs. female	0.8	0.5–1.3	0.406	1.1	0.6–1.9	0.808
Age (in decades)	1.7	1.2–1.8	<0.001 *	1.6	1.3–2.0	<0.001 *
NSND vs. SD	1.7	1.0–2.8	0.050 *	1.2	0.6–2.1	0.630
T3/4 vs. T1/2	2.9	1.7–5.0	<0.001 *	2.6	1.5–4.4	0.001 *
LN+ vs. LN-	2.3	1.4–3.8	0.001 *	2.0	1.1–3.6	0.019 *
PNI+ vs. PNI-	1.7	1.0–3.1	0.064	1.5	0.8–2.7	0.211
LVI+ vs. LVI-	2.0	1.0–4.0	0.064	1.4	0.6–3.1	0.443
EGFR Amplification	2.7	1.4–5.4	0.004 *	1.8	0.9–3.6	0.118
Male vs. female	0.8	0.5–1.3	0.406	1.1	0.6–1.9	0.861
Age (in decades)	1.7	1.2–1.8	<0.001 *	1.6	1.3–2.1	<0.001 *
NSND vs. SD	1.7	1.0–2.8	0.050 *	1.1	0.6–2.0	0.829
T3/4 vs. T1/2	2.9	1.7–5.0	<0.001 *	2.4	1.4–4.2	0.001 *
LN+ vs. LN-	2.3	1.4–3.8	0.001 *	2.0	1.1–3.7	0.016 *
PNI+ vs. PNI-	1.7	1.0–3.1	0.064	1.4	0.7–2.6	0.301
LVI+ vs. LVI-	2.0	1.0–4.0	0.064	1.5	0.6–3.3	0.360
CDKN2A Deletion	2.8	1.1–7.1	0.026 *	1.8	0.6–5.0	0.261
Male vs. female	0.8	0.5–1.3	0.406	1.0	0.6–1.9	0.932
Age (in decades)	1.7	1.2–1.8	<0.001 *	1.6	1.3–2.0	<0.001 *
NSND vs. SD	1.7	1.0–2.8	0.050 *	1.2	0.6–2.3	0.556
T3/4 vs. T1/2	2.9	1.7–5.0	<0.001 *	2.3	1.3–4.1	0.004 *
LN+ vs. LN-	2.3	1.4–3.8	0.001 *	2.2	1.2–4.1	0.009 *
PNI+ vs. PNI-	1.7	1.0–3.1	0.064	1.5	0.8–2.8	0.172
LVI+ vs. LVI-	2.0	1.0–4.0	0.064	1.2	0.5–2.8	0.654