Table 4.
Distribution of mutational alterations, comparing the SD group with the entire NSND group or subset of with low or high mutation load. NSND = non-smoker and non-drinker; SD = smokers and/or drinker. * p < 0.05.
| Alteration | SD (n = 117, 434 Mutations) |
NSND, All (n = 59, 366 Mutations) |
NSND, Low Mutation Group (n = 54, 233 Mutations) |
NSND, High Mutation Group (n = 5, 133 Mutations) |
|---|---|---|---|---|
| C > A | 60 (13.8) | 39 (10.7) | 27 (11.6) | 12 (9.6) |
| C>G | 44 (10.1) | 42 (11.5) | 27 (11.6) | 15 (12.0) |
| C>T | 178 (41.0) | 164 (44.8) | 107 (45.9) | 57 (45.6) |
| T>A | 33 (7.6) | 12 (3.3) | 6 (2.6) | 6 (4.8) |
| T > C | 47 (10.8) | 61 (16.7) | 35 (15.0) | 26 (20.8) |
| T>G | 18 (4.1) | 16 (4.4) | 7 (3.0) | 9 (7.2) |
| Indel | 54 (12.4) | 32 (8.7) | 24 (10.3) | 8 (6.0) |
| Compared to SD | p = 0.010 * | p = 0.067 | p = 0.019 * | |
| Compared to NSND | p = 0.297 |