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. 2021 Feb 28;22(5):2421. doi: 10.3390/ijms22052421

Figure 1.

Figure 1

Overview of important miRNAs as mediators of oxidative stress in POAG. Summary of the miRNAs (red) involved in the protective mechanisms against oxidative stress in POAG. miR-7, miR-24, miR-27a, miR-29b, miR-4295 have an anti-oxidant effect in TM cells (surrounded by the blue arrows), while miR-182 reduces oxidative stress damage in RGC (surrounded by the green arrow). The following abbreviations refer to TM (trabecular meshwork), RGC (retinal ganglion cells), LBPs (Lycium barbarum polysaccharides), FBN (fibrillin), ECM (extracellular matrix), SOD (superoxide dismutase), TGF-β2 (transforming growth factor-beta 2), NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), TLR4 (toll-like receptor 4), and Nrf2 (nuclear factor erythroid 2-related factor 2).