Table 2.
Multivariable analysis for correlates of incident events in outpatients with atrial fibrillation.
| Ischemic Stroke/Systemic Embolism | Major Bleeding | Hospitalization for Decompensated HF |
|
|---|---|---|---|
| Age (per year) | 1.04 [1.02–1.06] p < 0.001 |
1.03 [1.02–1.05] p < 0.001 |
1.04 [1.03–1.05] p < 0.001 |
| Women | - | - | 1.21 [1.01–1.45] p = 0.044 |
| Hypertension | - | - | 1.32 [1.08–1.60] p = 0.006 |
| Diabetes mellitus | - | 1.41 [1.02–1.94] p = 0.037 |
1.60 [1.34–1.91] p < 0.001 |
| Permanent AF | - | - | - |
| Underlying mechanical prosthetic valve or moderate to severe mitral stenosis | 1.66 [1.12–2.46] p = 0.011 |
||
| LVEF (per %) | - | - | 0.97 [0.96–0.98] p < 0.001 |
| History of CAD | - | - | 1.30 [1.08–1.56] p = 0.005 |
| History of HF | 1.57 [1.09–2.25] p = 0.016 |
1.83 [1.36–2.47] p < 0.001 |
2.83 [2.31–3.47] p < 0.001 |
| Previous stroke | 2.23 [1.39–3.59] p = 0.001 |
1.65 [1.06–2.55] p = 0.026 |
- |
| History of PAD | 1.84 [1.19–2.84] p = 0.006 |
- | - |
Data are hazard ratios [95% confidence intervals] and p values. Multivariable analysis was performed using a stepwise approach with forward selection (the p value for entering into the model was set at 0.05). HF, heart failure; AF, atrial fibrillation; LVEF, left ventricular ejection fraction; CAD, coronary artery disease; PAD, peripheral artery disease.