Table 1.
Sociodemographic, clinical variables and neuropsychological evaluations of subjects in the groups.
| Control | aMCI | Mild AD | |
|---|---|---|---|
| Sex (F/M) | 8/0 | 5/2 | 7/0 |
| Age | 63.7 ± 3.7 | 71.1 ± 6 | 72.7 ± 7 |
| Scholarity (years ± SD) | 10.2 ± 5.37 | 7.4 ± 4.4 | 7.1 ± 4.3 |
| CDR 0 (n) | 8 | 7 | 0 |
| CDR 1(n) | 0 | 0 | 7 |
| CDR2 (n) | 0 | 0 | 0 |
| MEEM (mean ± SD) | 28.3 ± 2.3 | 27 ± 2.1 ** | 19.5 ± 3.6 *** |
| CSF t-tau (pg/mL ± SD) | 80.3 ± 38.4 | 103.3 ± 32.8 | 156.0 ± 86.4 * |
| CSF p-tau181 (pg/mL ± SD) | 35 ± 16.6 | 38 ± 9.7 | 62.6 ± 37.5 * |
| β-amyloid (pg/mL ± SD) | 541.7 ± 302.2 | 530.3 ± 365.2 | 303.2 ± 107.0 |
| CSF ADAM10 (AU) | 0.1475 ± 0.0551 | 0.1598 ± 0.0707 * | 0.3323 ± 0.1185 *,† |
| Plasma ADAM10 (AU) | 0.6805 ± 0.3171 | 0.9512 ± 0.2362 ** | 2.362 ± 0.7428 **,† |
* p < 0.05 (Control vs mild AD; aMCI vs mild AD); ** p < 0.01 (Control vs mild AD; aMCI vs mild AD); *** p < 0.001 (Control vs mild AD) in Mann-Whitney U-test; † One-Way ANOVA (p = 0.02 in CSF; p = 0.001 in plasma). Graph Pad Prism 5.2.