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. 2021 Feb 28;22(5):2419. doi: 10.3390/ijms22052419

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The exposome concept. (A) The exposome comprises the totality of a person’s external and internal exposures, from birth to death. (B) The external exposures and their internal exposure-related biochemical changes accumulate steadily over the aging process and lead to altered health risks. Adapted from Vrijheid et al. [2] (upper part, Copyright © 2021, BMJ Publishing Group Ltd. and the British Thoracic Society) and Misra [3] (lower part, under the terms of the Creative Commons Attribution License (CC BY), Copyright © 2021 Misra) with permission.