Figure 2.

CaSR in CVDs. CaSR is implicated in various cardiovascular disorders, where it exerts its role by influencing various factors involved in the development and progression of the disease. CaSR is involved in myocardial ischemia, vascular calcification, hypertension, atherosclerosis, and obesity induced CVDs. This figure gives a brief summary of the involvement of CaSR in the above-mentioned CVDs and the ways in which CaSR influences each one of them (created with BioRender.com). ER: endoplasmic reticulum; NLRP3: NLR family pyrin domain containing 3; ^●NO: nitric oxide.