Table 1.
IC50 (µM) values of NLSPE5 and onconase for a panel of tumor and non-tumor cell lines.
| Cell Line | Origin | ONC IC50 (μM) | NLSPE5 IC50 (μM) | |
|---|---|---|---|---|
| Tumor Cell Lines | NCI-H460 | Large cell lung carcinoma | 0.40 ± 0.06 | 0.15 ± 0.05 |
| OVCAR-8 | Ovarian serous adenocarcinoma | 0.54 ± 0.08 | 0.24 ± 0.04 | |
| NCI-H460/R | NCI-H460 doxorubicin resistant | 0.50 ± 0.10 | 0.40 ± 0.10 | |
| Sk-Br-3 | Breast cancer derived from metastatic pleural effusion | 4.20 ± 0.60 | 0.36 ± 0.09 | |
| HeLa | Cervix carcinoma | 0.15 ± 0.02 | 0.26 ± 0.04 | |
| Non-Tumor Cell Lines | HaCaT | Spontaneously transformed keratinocyte | 0.70 ± 0.09 | 0.92 ± 0.14 |
| CCD-18Co | Colon fibroblasts | 0.56 ± 0.10 | 7.10 ± 1.04 | |
| HEK-293 | Embryonic kidney cells | 0.28 ± 0.05 | 0.74 ± 0.18 | |
| 1BR3G | Skin transformed fibroblasts | 0.50 ± 0.13 | 0.75 ± 0.10 | |
| MCF10A | Epithelial mammary gland | 1.07 ± 0.07 | 1.50 ± 0.09 |